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Table 3 Associations of extent of mammographic breast density with breast cancer risk in women with atypical hyperplasia

From: Mammographic breast density and risk of breast cancer in women with atypical hyperplasia: an observational cohort study from the Mayo Clinic Benign Breast Disease (BBD) cohort

 

Low Density

Medium Density

High Density

p-valuea

Characteristic

N

Obs

Exp

SIR (95% CI)

N

Obs

Exp

SIR (95% CI)

N

Obs

Exp

SIR (95% CI)

Overall

69

12

3.53

3.40 (1.76, 5.93)

231

41

11.77

3.48 (2.50, 4.73)

170

29

8.92

3.25 (2.18, 4.67)

0.96

Type of Density Measure

 PPAT

60

11

3.16

3.48 (1.74, 6.23)

91

17

5.39

3.15 (1.84, 5.05)

131

24

7.33

3.28 (2.10, 4.87)

0.97

 BIRADS

9

1

0.37

2.73 (0.07, 15.13)

140

24

6.37

3.77 (2.41, 5.60)

39

5

1.59

3.14 (1.02, 7.31)

0.89

Age at Biopsy

  < 45

7

2

0.30

6.61 (0.80, 23.79)

15

2

0.32

6.17 (0.75, 22.21)

32

4

1.20

3.33 (0.91, 8.53)

0.66

 45-55

9

0

0.39

NA

76

15

3.64

4.12 (2.31, 6.80)

67

14

3.65

3.84 (2.10, 6.44)

0.21

 55+

53

10

2.84

3.53 (1.69, 6.49)

140

24

7.80

3.08 (1.97, 4.58)

71

11

4.07

2.70 (1.35, 4.84)

0.83

Number of Atypical Foci

 1

47

6

2.73

2.20 (0.81, 4.79)

126

19

6.80

2.79 (1.68, 4.36)

96

16

4.76

3.36 (1.92, 5.46)

0.65

 2

15

4

0.52

7.73 (2.11, 19.81)

61

14

2.81

4.98 (2.72, 8.36)

42

6

2.42

2.48 (0.91, 5.40)

0.16

 3+

7

2

0.29

6.98 (0.84, 25.13)

44

8

2.15

3.72 (1.61, 7.32)

32

7

1.74

4.03 (1.62, 8.29)

0.76

Type of Atypia

 ADH

41

7

2.18

3.21 (1.29, 6.61)

116

17

5.74

2.96 (1.73, 4.75)

65

15

3.48

4.31 (2.41, 7.11)

0.57

 ALH

27

5

1.28

3.92 (1.27, 9.12)

96

20

5.14

3.89 (2.38, 6.01)

96

13

4.92

2.64 (1.40, 4.52)

0.51

 ADH and ALH

1

0

0.08

NA

19

4

0.89

4.48 (1.22, 11.48)

9

1

0.51

1.94 (0.05, 10.79)

0.56

BMI at Biopsy

  < 25

25

2

1.45

1.38 (0.17, 4.97)

78

18

3.96

4.55 (2.69, 7.19)

101

17

5.17

3.29 (1.91, 5.27)

0.16

 25-29

19

5

1.01

4.96 (1.61, 11.55)

70

10

3.37

2.97 (1.42, 5.46)

35

4

1.95

2.05 (0.56, 5.25)

0.42

 30+

24

5

1.07

4.66 (1.51, 10.86)

81

13

4.39

2.96 (1.57, 5.07)

32

7

1.76

3.97 (1.60, 8.17)

0.65

  1. Standardized incidence ratios and corresponding 95% confidence intervals, comparing the observed number of breast cancer events to those expected based on incidence rates from Iowa SEER data. Analyses account for the effects of age and calendar period
  2. N number of individuals, Obs observed number of breast cancer events, Exp expected number of breast cancer events, SIR standardized incidence ratio, CI confidence interval
  3. a P-value, test of heterogeneity in SIRs across columns