Fig. 5

3D reconstruction of contrast CT images for HCC neovascularization at weeks 1 to 4 (a to d, respectively). The selected areas with red dot lines show the tumor regions, (e to f) enlarged image of the rectangle region of d, which clearly shows the disorganized distribution and morphology of tumor neovascularization. A large number of avascular regions were observed in the tumors at weeks 3 and 4 (c, d), as well as irregular vessel shape with dendritic-like branching (e), individual vascular curvature abnormalities (f), blood vessel network cluster structure (g), a large number of tiny and curved vessels derived from a few thick vessels (h, red arrows), and compressed tumor edge or peripheral vasculature (c, d)