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Table 3 Multivariate Cox regression analysis for OS of 142 patients with NPC

From: Higher IGFBP-1 to IGF-1 serum ratio predicts unfavourable survival in patients with nasopharyngeal carcinoma

Characteristic Overall Survival Relapse-Free Survival
HR 95% CI P value HR 95% CI P value
 Gender
  Male vs. Female 0.225 0.053–0.950 0.042* 0.247 0.075–0.819 0.022*
 Age (y)
   < 46 vs. ≥46 1.389 0.673–2.867 0.374 2.099 1.027–4.293 0.042*
 Tumor size
  T1 + T2 vs. T3 + T4 0.873 0.292–2.611 0.809 0.972 0.325–2.905 0.959
 Lymphoid nodal states
  N0-1 vs. N2-3 2.312 0.969–5.519 0.050* 2.662 1.146–6.187 0.023*
 Clinical Stage
  1 + 2 vs. 3 + 4 0.798 0.327–1.945 0.619 0.856 0.284–2.579 0.783
 Local-regional relapse
  Yes vs. NO 2.296 1.013–5.204 0.047* 23.877 9.554–59.668 0.000*
 Metastasis
  Yes vs. No 9.085 1.871–44.128 0.006* 5.045 1.195–21.288 0.028*
 WHO histological classification
  NKUC vs. NKDC 0.680 0.148–3.121 0.620 0.580 0.129–2.609 0.477
 EA
   ≤ 1:10 vs. >1:10 0.568 0.234–1.381 0.212 0.679 0.275–1.677 0.401
 VCA
   ≤ 1:40 vs. >1:40 0.613 0.207–1.816 0.377 0.376 0.131–1.084 0.070
 IGFBP-1
  Low vs. High 0.802 0.330–1.947 0.626 0.520 0.213–1.267 0.150
 IGF-1
  Low vs. High 1.649 0.612–4.443 0.323 1.450 0.602–3.490 0.407
 IGFBP-1/IGF-1
   > 1 vs. ≤1 0.298 0.096–0.920 0.035* 0.334 0.115–0.969 0.044*
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