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Table 1 Mutation analysis in different histological areas

From: Stepwise addition of genetic changes correlated with histological change from “well-differentiated” to “sarcomatoid” phenotypes: a case report

Histological area

Gene

Mutation

Position

Ref

Variant in tumor

AF

Portion A: well diff. Adeno

TP53

p.V118F

chr17:7578461

C

A

47%

 

KRAS

p.G12V

chr12:25398284

C

A

30%

Portion B: poorly diff. Adeno

KRAS

p.G12V

chr12:25398284

C

A

97%

 

TP53

p.V118F

chr17:7578461

C

A

86%

Portion C: sarcomatoid

TP53

p.V118F

chr17:7578461

C

A

70%

 

KRAS

p.G12V

chr12:25398284

C

A

52%

  1. The table listed somatic mutations with an allele fraction ≥30%
  2. chr chromosome, Ref reference sequence, AF allele fraction
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BMC Cancer

ISSN: 1471-2407

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