Skip to main content
Fig. 6 | BMC Cancer

Fig. 6

From: The acceleration of glucose accumulation in renal cell carcinoma assessed by FDG PET/CT demonstrated acquisition of resistance to tyrosine kinase inhibitor therapy

Fig. 6

Accelerated FDG accumulation during TKI treatment can be dependent on mTOR activity. a 50’s-year-old patient with liver metastases (#23). The FDG accumulation of liver metastasis that accelerated during 4 months of sunitinib treatment was suppressed by 1 month of everolimus treatment. b The expression of GLUT-1, Cyclin D, and HIF-2 α was accelerated in the 786-O cells that survived under a hypoxic condition. The overexpression of these proteins induced by hypoxia was suppressed by 20nM rapamycin

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us