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Fig. 5 | BMC Cancer

Fig. 5

From: Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer

Fig. 5

Survival Curve. Survival of mice treated with (a) PB28; (b) PB221; (c) PB183; (d) F281; (e) PB282 compared to the mice treated with vehicle (p > 0.05 for PB221 and p < 0.05 for all the other compounds) or Gemzar. Survival endpoints were defined as tumor diameter > 15 mm or tumor ulceration

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