Fig. 5From: Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancerSurvival Curve. Survival of mice treated with (a) PB28; (b) PB221; (c) PB183; (d) F281; (e) PB282 compared to the mice treated with vehicle (p > 0.05 for PB221 and p < 0.05 for all the other compounds) or Gemzar. Survival endpoints were defined as tumor diameter > 15 mm or tumor ulcerationBack to article page