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Fig. 3 | BMC Cancer

Fig. 3

From: Sigma-2 receptor agonist derivatives of 1-Cyclohexyl-4-[3-(5-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)propyl]piperazine (PB28) induce cell death via mitochondrial superoxide production and caspase activation in pancreatic cancer

Fig. 3

Sigma-2 Ligands generate Superoxide Radical in the Mitochondria. Mitochondrial Superoxide detection in (a) Panc02, (b) AsPC-1, (c) KP02, (d) BxPC3, after 2 h treatment with 50 μM sigma-2 ligands alone or in combination with the lipid antioxidant α-tocopherol (1 mM). Values are the means of n ≥ 3 independent experiments in triplicates with SEM, p < 0.0001

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