Continuous QOL variables | Dichotomized QOL variables | Index score | |||||||
---|---|---|---|---|---|---|---|---|---|
HR | 95% CI | p-value | HR | 95% CI | p-value | HR | 95% CI | p-value | |
EORTC QLQ-C30 | |||||||||
Physical Functioning | 0.652 | 0.495–0.860 | 0.0024 | 1.475 | 1.095–1.986 | 0.0106 | - | - | - |
Pain | 1.346 | 1.092–1.661 | 0.0055 | 1.523 | 1.192–1.947 | 0.0008 | - | - | - |
Financial difficulties | - | - | - | 1.331 | 1.059–1.673 | 0.0141 | - | - | - |
C30 Index score | - | - | - | - | - | - | 2.143 | 1.616–2.841 | <0.0001 |
Portal vein thrombosis | 1.723 | 1.342–2.212 | <0.0001 | 1.702 | 1.325–2.187 | <0.0001 | 1.661 | 1.291–2.136 | <0.0001 |
Tumor Morphology – Multinodular | 1.604 | 1.147–2.243 | 0.0058 | 1.614 | 1.152–2.260 | 0.0054 | 1.719 | 1.229–2.403 | 0.0015 |
Tumor Morphology – Diffuse | 2.449 | 1.763–3.401 | <0.0001 | 2.556 | 1.841–3.550 | <0.0001 | 2.636 | 1.902–3.651 | <0.0001 |
Albumin ≤35g/l | 1.442 | 1.125–1.848 | 0.0039 | 1.541 | 1.199–1.981 | 0.0007 | 1.641 | 1.311–2.055 | <0.0001 |
Bilirubin ≥20umol/l | 1.785 | 1.400–2.275 | <0.0001 | 1.784 | 1.398–2.277 | <0.0001 | 1.752 | 1.390–2.208 | <0.0001 |
α-fetoprotein ≥200 ng/ml | 1.830 | 1.439–2.328 | <0.0001 | 1.878 | 1.476–2.389 | <0.0001 | 1.749 | 1.380–2.218 | <0.0001 |
Extrahepatic metastasis | 1.696 | 1.303–2.209 | <0.0001 | 1.753 | 1.342–2.288 | <0.0001 | 1.805 | 1.386–2.351 | <0.0001 |
Alkaline phosphatase >2xULN | 1.456 | 1.145–1.852 | 0.0022 | 1.420 | 1.116–1.806 | 0.0043 | 1.472 | 1.159–1.870 | 0.0015 |
Creatinine ≥ ULN | 1.538 | 1.129–2.094 | 0.0063 | 1.637 | 1.204–2.227 | 0.0017 | 1.712 | 1.263–2.322 | 0.0005 |
Ascites | 1.327 | 1.015–1.736 | 0.0385 | 1.325 | 1.012–1.734 | 0.0408 | - | - | - |
EORTC QLQ-HCC18 | |||||||||
Fatigue | 1.441 | 1.132–1.833 | 0.0030 | 1.805 | 1.411–2.310 | <0.0001 | - | - | - |
Pain | 1.382 | 1.089–1.754 | 0.0077 | - | - | - | - | - | - |
HCC18 index score | - | - | - | - | - | - | 1.957 | 1.411–2.715 | <0.0001 |
Portal vein thrombosis | 1.701 | 1.320–2.191 | <0.0001 | 1.672 | 1.295–2.160 | <0.0001 | 1.688 | 1.312–2.172 | <0.0001 |
Tumor Morphology – Multinodular | 1.638 | 1.172–2.289 | 0.0038 | 1.709 | 1.223–2.388 | 0.0017 | 1.681 | 1.203–2.348 | 0.0024 |
Tumor Morphology – Diffuse | 2.510 | 1.805–3.490 | <0.0001 | 2.813 | 2.034–3.891 | <0.0001 | 2.624 | 1.893–3.637 | <0.0001 |
Albumin ≤35g/l | 1.684 | 1.344–2.111 | <0.0001 | 1.704 | 1.360–2.135 | <0.0001 | 1.666 | 1.329–2.088 | <0.0001 |
Bilirubin ≥20umol/l | 1.687 | 1.333–2.134 | <0.0001 | 1.662 | 1.316–2.100 | <0.0001 | 1.659 | 1.312–2.098 | <0.0001 |
α-fetoprotein ≥200 ng/ml | 1.744 | 1.371–2.218 | <0.0001 | 1.805 | 1.423–2.289 | <0.0001 | 1.735 | 1.367–2.201 | <0.0001 |
Extrahepatic metastasis | 1.788 | 1.370–2.334 | <0.0001 | 1.830 | 1.402–2.389 | <0.0001 | 1.773 | 1.361–2.309 | <0.0001 |
Alkaline phosphatase >2xULN | 1.426 | 1.124–1.810 | 0.0035 | 1.341 | 1.054–1.705 | 0.0169 | 1.445 | 1.139–1.832 | 0.0024 |
Creatinine ≥ ULN | 1.695 | 1.249–2.301 | 0.0007 | 1.600 | 1.181–2.167 | 0.0024 | 1.701 | 1.253–2.348 | 0.0007 |