Table 3 Multivariate analysis of HRQOL variables or index scores with significant clinical factors (n = 472)

 Physical Functioning

0.652

0.495–0.860

0.0024

1.475

1.095–1.986

0.0106

-

-

-

 Pain

1.346

1.092–1.661

0.0055

1.523

1.192–1.947

0.0008

-

-

-

 Financial difficulties

-

-

-

1.331

1.059–1.673

0.0141

-

-

-

 C30 Index score

-

-

-

-

-

-

2.143

1.616–2.841

<0.0001

 Portal vein thrombosis

1.723

1.342–2.212

<0.0001

1.702

1.325–2.187

<0.0001

1.661

1.291–2.136

<0.0001

 Tumor Morphology – Multinodular

1.604

1.147–2.243

0.0058

1.614

1.152–2.260

0.0054

1.719

1.229–2.403

0.0015

 Tumor Morphology – Diffuse

2.449

1.763–3.401

<0.0001

2.556

1.841–3.550

<0.0001

2.636

1.902–3.651

<0.0001

 Albumin ≤35g/l

1.442

1.125–1.848

0.0039

1.541

1.199–1.981

0.0007

1.641

1.311–2.055

<0.0001

 Bilirubin ≥20umol/l

1.785

1.400–2.275

<0.0001

1.784

1.398–2.277

<0.0001

1.752

1.390–2.208

<0.0001

 α-fetoprotein ≥200 ng/ml

1.830

1.439–2.328

<0.0001

1.878

1.476–2.389

<0.0001

1.749

1.380–2.218

<0.0001

 Extrahepatic metastasis

1.696

1.303–2.209

<0.0001

1.753

1.342–2.288

<0.0001

1.805

1.386–2.351

<0.0001

 Alkaline phosphatase >2xULN

1.456

1.145–1.852

0.0022

1.420

1.116–1.806

0.0043

1.472

1.159–1.870

0.0015

 Creatinine ≥ ULN

1.538

1.129–2.094

0.0063

1.637

1.204–2.227

0.0017

1.712

1.263–2.322

0.0005

 Ascites

1.327

1.015–1.736

0.0385

1.325

1.012–1.734

0.0408

-

-

-

 Fatigue

1.441

1.132–1.833

0.0030

1.805

1.411–2.310

<0.0001

-

-

-

 Pain

1.382

1.089–1.754

0.0077

-

-

-

-

-

-

 HCC18 index score

-

-

-

-

-

-

1.957

1.411–2.715

<0.0001

 Portal vein thrombosis

1.701

1.320–2.191

<0.0001

1.672

1.295–2.160

<0.0001

1.688

1.312–2.172

<0.0001

 Tumor Morphology – Multinodular

1.638

1.172–2.289

0.0038

1.709

1.223–2.388

0.0017

1.681

1.203–2.348

0.0024

 Tumor Morphology – Diffuse

2.510

1.805–3.490

<0.0001

2.813

2.034–3.891

<0.0001

2.624

1.893–3.637

<0.0001

 Albumin ≤35g/l

1.684

1.344–2.111

<0.0001

1.704

1.360–2.135

<0.0001

1.666

1.329–2.088

<0.0001

 Bilirubin ≥20umol/l

1.687

1.333–2.134

<0.0001

1.662

1.316–2.100

<0.0001

1.659

1.312–2.098

<0.0001

 α-fetoprotein ≥200 ng/ml

1.744

1.371–2.218

<0.0001

1.805

1.423–2.289

<0.0001

1.735

1.367–2.201

<0.0001

 Extrahepatic metastasis

1.788

1.370–2.334

<0.0001

1.830

1.402–2.389

<0.0001

1.773

1.361–2.309

<0.0001

 Alkaline phosphatase >2xULN

1.426

1.124–1.810

0.0035

1.341

1.054–1.705

0.0169

1.445

1.139–1.832

0.0024

 Creatinine ≥ ULN

1.695

1.249–2.301

0.0007

1.600

1.181–2.167

0.0024

1.701

1.253–2.348

0.0007