Skip to main content

Table 3 Multivariate analysis of HRQOL variables or index scores with significant clinical factors (n = 472)

From: Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma – clinical application of health-related quality-of-life data

  Continuous QOL variables Dichotomized QOL variables Index score
  HR 95% CI p-value HR 95% CI p-value HR 95% CI p-value
EORTC QLQ-C30
 Physical Functioning 0.652 0.495–0.860 0.0024 1.475 1.095–1.986 0.0106 - - -
 Pain 1.346 1.092–1.661 0.0055 1.523 1.192–1.947 0.0008 - - -
 Financial difficulties - - - 1.331 1.059–1.673 0.0141 - - -
 C30 Index score - - - - - - 2.143 1.616–2.841 <0.0001
 Portal vein thrombosis 1.723 1.342–2.212 <0.0001 1.702 1.325–2.187 <0.0001 1.661 1.291–2.136 <0.0001
 Tumor Morphology – Multinodular 1.604 1.147–2.243 0.0058 1.614 1.152–2.260 0.0054 1.719 1.229–2.403 0.0015
 Tumor Morphology – Diffuse 2.449 1.763–3.401 <0.0001 2.556 1.841–3.550 <0.0001 2.636 1.902–3.651 <0.0001
 Albumin ≤35g/l 1.442 1.125–1.848 0.0039 1.541 1.199–1.981 0.0007 1.641 1.311–2.055 <0.0001
 Bilirubin ≥20umol/l 1.785 1.400–2.275 <0.0001 1.784 1.398–2.277 <0.0001 1.752 1.390–2.208 <0.0001
 α-fetoprotein ≥200 ng/ml 1.830 1.439–2.328 <0.0001 1.878 1.476–2.389 <0.0001 1.749 1.380–2.218 <0.0001
 Extrahepatic metastasis 1.696 1.303–2.209 <0.0001 1.753 1.342–2.288 <0.0001 1.805 1.386–2.351 <0.0001
 Alkaline phosphatase >2xULN 1.456 1.145–1.852 0.0022 1.420 1.116–1.806 0.0043 1.472 1.159–1.870 0.0015
 Creatinine ≥ ULN 1.538 1.129–2.094 0.0063 1.637 1.204–2.227 0.0017 1.712 1.263–2.322 0.0005
 Ascites 1.327 1.015–1.736 0.0385 1.325 1.012–1.734 0.0408 - - -
EORTC QLQ-HCC18
 Fatigue 1.441 1.132–1.833 0.0030 1.805 1.411–2.310 <0.0001 - - -
 Pain 1.382 1.089–1.754 0.0077 - - - - - -
 HCC18 index score - - - - - - 1.957 1.411–2.715 <0.0001
 Portal vein thrombosis 1.701 1.320–2.191 <0.0001 1.672 1.295–2.160 <0.0001 1.688 1.312–2.172 <0.0001
 Tumor Morphology – Multinodular 1.638 1.172–2.289 0.0038 1.709 1.223–2.388 0.0017 1.681 1.203–2.348 0.0024
 Tumor Morphology – Diffuse 2.510 1.805–3.490 <0.0001 2.813 2.034–3.891 <0.0001 2.624 1.893–3.637 <0.0001
 Albumin ≤35g/l 1.684 1.344–2.111 <0.0001 1.704 1.360–2.135 <0.0001 1.666 1.329–2.088 <0.0001
 Bilirubin ≥20umol/l 1.687 1.333–2.134 <0.0001 1.662 1.316–2.100 <0.0001 1.659 1.312–2.098 <0.0001
 α-fetoprotein ≥200 ng/ml 1.744 1.371–2.218 <0.0001 1.805 1.423–2.289 <0.0001 1.735 1.367–2.201 <0.0001
 Extrahepatic metastasis 1.788 1.370–2.334 <0.0001 1.830 1.402–2.389 <0.0001 1.773 1.361–2.309 <0.0001
 Alkaline phosphatase >2xULN 1.426 1.124–1.810 0.0035 1.341 1.054–1.705 0.0169 1.445 1.139–1.832 0.0024
 Creatinine ≥ ULN 1.695 1.249–2.301 0.0007 1.600 1.181–2.167 0.0024 1.701 1.253–2.348 0.0007
  1. ULN upper limit of normal, CI confidence interval, HR hazard ratio, HRQOL health-related quality of life