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Table 2 Baseline HRQOL and univariate analyses using continuous, dichotomized variables, C30 and HCC18 index scores for patients with complete HRQOL data (n = 472)a

From: Prognostic values of EORTC QLQ-C30 and QLQ-HCC18 index-scores in patients with hepatocellular carcinoma – clinical application of health-related quality-of-life data

 

Mean

±SD

Continuous variables

Dichotomized variablesa

 

HR [95% CI]

p-value

HR [95% CI]

p-value

EORTC QLQ-C30

 Physical Functioning

72.27

23.74

0.432 [0.351–0.533]

<0.0001

2.026 [1.571–2.612]

<0.0001

 Role Functioning

74.61

32.60

0.517 [0.443–0.603]

<0.0001

2.108 [1.645–2.702]

<0.0001

 Emotional Functioning

70.67

25.48

0.777 [0.632–0.954]

0.0164

1.448 [1.100–1.908]

0.0084

 Social Functioning

76.80

24.68

0.698 [0.571–0.853]

0.0004

1.611 [1.162–2.234]

0.0042

 Cognitive Function

68.46

30.33

0.634 [0.531–0.756]

<0.0001

1.573 [1.233–2.007]

0.0003

 Global Quality of Life

52.22

26.34

0.515 [0.417–0.635]

<0.0001

1.611 [1.299–1.998]

<0.0001

 Fatigue

42.93

30.23

1.973 [1.657–2.349]

<0.0001

2.072 [1.672–2.568]

<0.0001

 Nausea/Vomiting

11.26

21.41

2.050 [1.643–2.559]

<0.0001

2.308 [1.679–3.173]

<0.0001

 Pain

32.87

31.97

1.865 [1.584–2.197]

<0.0001

2.108 [1.698–2.617]

<0.0001

 Dyspnoea

29.73

31.46

1.396 [1.189–1.639]

<0.0001

1.666 [1.314–2.113]

<0.0001

 Insomnia

41.88

36.41

1.344 [1.162–1.556]

<0.0001

1.415 [1.144–1.750]

0.0014

 Appetite loss

32.34

35.88

1.923 [1.668–2.217]

<0.0001

2.360 [1.889–2.949]

<0.0001

 Constipation

16.67

27.13

1.201 [0.999–1.444]

0.0512

1.368 [1.021–1.834]

0.0359

 Diarrhea

16.45

26.87

1.520 [1.252–1.845]

<0.0001

1.666 [1.248–2.224]

0.0005

 Financial difficulties

51.20

37.22

1.353 [1.169–1.566]

<0.0001

1.579 [1.276–1.954]

<0.0001

 C30 index score

30.69

19.61

3.658 [2.726–4.909]

<0.0001

-

-

EORTC QLQ-HCC18

 Fatigue

35.23

25.86

2.381 [1.942–2.919]

<0.0001

2.484 [1.968–3.136]

<0.0001

 Body Image

25.35

22.98

2.261 [1.819–2.811]

<0.0001

2.167 [1.718–2.733]

<0.0001

 Jaundice

23.41

22.15

1.289 [1.024–1.623]

0.0307

1.271 [0.977–1.652]

0.0739

 Nutrition

26.96

21.35

2.934 [2.317–3.716]

<0.0001

2.663 [2.026–3.502]

<0.0001

 Pain

23.34

24.57

2.107 [1.717–2.587]

<0.0001

1.871 [1.465–2.391]

<0.0001

 Fever

6.60

14.39

1.568 [1.123–2.187]

0.0081

1.697 [0.929–3.099]

0.0851

 Sex life

28.74

34.76

1.213 [1.040–1.415]

0.0139

1.436 [1.128–1.828]

0.0033

 Abdominal swelling

33.33

35.43

1.721 [1.486–1.994]

<0.0001

2.192 [1.752–2.743]

<0.0001

 HCC18 index score

25.37

17.21

3.028 [2.340–3.919]

<0.0001

-

-

  1. C30 index-score = ∑ [(100-Physical functioning), (100-Role functioning), (100-Emotional functioning), (100-Cognitive functioning), (100-Social functioning), (100-global QOL), scores of Fatigue, Nausea/vomiting, Pain, Dyspnoea, Insomnia, Appetite loss, Constipation, Diarrhea, Financial Diffculty] ÷ 15
  2. HCC18 index-score = ∑ (scores of Fatigue, Body Image, Jaundice, Nutrition, Pain, Fever, Sex life, Abdominal distension) ÷ 8
  3. aIn dichotomization, worse (≥50 in symptoms/problem or <50 in functioning/global QOL) scores in QLQ-C30 were analyzed with respect to better scores; worse (≥50) scores in QLQ-HCC18 were analyzed with respect to better scores
  4. SD standard deviation, CI confidence interval, HR hazard ratio, HRQOL health-related quality of life
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BMC Cancer

ISSN: 1471-2407

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