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Table 3 Univariate and multivariate analysis of pr4gression-free survival (PFS) (n = 90)

From: Retrospective study of RAS/PIK3CA/BRAF tumor mutations as predictors of response to first-line chemotherapy with bevacizumab in metastatic colorectal cancer patients

Variable Univariate analysis Multivariate analysis
HR (95% CI) P value HR (95% CI) P value
Sex
 Male vs. female 1.0 vs. 0.72 (0.42–1.24) 0.236   
Age
  < 63 y.o vs. ≥63 y.o 1.0 vs. 0.82 (0.48–1.40) 0.472   
ECOG PS
 0 vs. 1,2 1.0 vs. 0.66 (0.21–2.14) 0.490   
Site of primary tumor
 RCC vs. LCRC 1.0 vs. 0.88 (0.51–1.52) 0.643   
Differentiated-type
 yes vs. no 1.0 vs. 1.78 (0.75–4.22) 0.188   
Synchronous mets
 yes vs. no 1.0 vs. 0.61 (0.29–1.30) 0.201   
Sites of metastasis
 Non-liver vs. liver 1.0 vs. 1.84 (1.06–3.20) 0.031 1.0 vs. 3.26 (1.57–6.77) 0.002
 Non-lung vs. lung 1.0 vs. 1.17 (0.68–2.00) 0.567   
 Non-LN vs. LN 1.0 vs. 0.67 (0.37–1.20) 0.177   
 Non-P vs. P 1.0 vs. 0.95 (0.51–1.78) 0.878   
Number of metastases
 1 vs. ≥2 1.0 vs. 0.87 (0.51–1.50) 0.628   
Primary resection
 yes vs. no 1.0 vs. 2.00 (1.09–3.66) 0.024 1.0 vs. 2.13 (1.05–4.29) 0.035
Prior L-OHP
 yes vs. no 1.0 vs. 0.75 (0.35–1.60) 0.457   
ALP (/)
  ≤ ULN vs. >ULN 1.0 vs. 1.07 (0.56–2.04) 0.836   
LDH (/IU)
  ≤ ULN vs. >ULN 1.0 vs. 1.27 (0.74–2.21) 0.387   
CRP (mg/dl)
  ≤ ULN vs. >ULN 1.0 vs. 2.35 (1.32–4.17) <0.001 1.0 vs. 1.57 (0.79–3.10) 0.196
CEA
  ≤ ULN vs. >ULN 1.0 vs. 0.90 (0.49–1.65) 0.735   
CA19-9
  ≤ ULN vs. >ULN 1.0 vs. 1.63 (0.95–2.80) 0.076   
RAS status
 Wild-type vs. mutant 1.0 vs. 1.36 (0.79–2.32) 0.264 1.0 vs. 2.01 (1.07–3.76) 0.030
PIK3CA status
 Wild-type vs. mutant 1.0 vs. 1.00 (0.36–2.77) 0.993 1.0 vs. 0.66 (0.21–2.03) 0.466
BRAF status
 Wild-type vs. mutant 1.0 vs. 1.60 (0.68–3.75) 0.285 1.0 vs. 3.87 (1.38–10.9) 0.010
  1. CI confidence interval, HR hazard ratio, RCC right-sided colon cancer, LCRC left-sided colorectal cancer, mets metastasis, LN lymph node, P peritoneum, ULN upper limit of normal, NA not assessable. All data in italics are with p-value <0.05