Table 1 Series of treatment outcomes of elderly patients undergoing SRS for BM
First author & year | Treatment modality | No. of patients | Median age (Cut-off age) | No. receiving prior WBRT (%) | MST after SRS (months) | Factors predicting longer OS | Local tumor control | Remote brain recurrence |
|---|---|---|---|---|---|---|---|---|
Noël, 2005 [12] | LINAC | 117 | 71 years (≥65 years) | 18 (15%) | 8 | KPS ≥ 70 | 98%/6 months 91%/2 years | 33%/6 months 60%/2 years |
Kim, 2008 [13] | LINAC/GK | 44 | 79 years (≥75 years) | 17 (39%) | a7.3 | Single BM | b88% | b81% |
Minniti, 2013 [14] | LINAC | 102 | 77 years (≥70 years) | 0 (0%) | 13.2 | KPS > 70, Stable extracranial disease | 90%/1 year 84%/2 years | 54%/1 year 78%/2 years |
Watanabe, 2014 [15] | GK | 165 | 82 years (≥80 years) | 4 (2%) | 5.3 | NR | b95% | NR |
Park, 2015 [16] | GK | 147 | 79 years (≥70 years) | 13 (9%) | 5.6 | KPS ≥ 90, No extracranial metastasis | NR | NR |
Present study, 2016 | GK | 106 | 84 years (≥80 years) | 0 (0%) | 7.1 | KPS ≥ 70, Controlled primary/no extracranial metastasis, Female sex | 94%/6 months 89%/1 year | 17%/6 months 25%/1 year |