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Table 1 Series of treatment outcomes of elderly patients undergoing SRS for BM

From: Is upfront stereotactic radiosurgery a rational treatment option for very elderly patients with brain metastases? A retrospective analysis of 106 consecutive patients age 80 years and older

First author & year Treatment modality No. of patients Median age (Cut-off age) No. receiving prior WBRT (%) MST after SRS (months) Factors predicting longer OS Local tumor control Remote brain recurrence
Noël, 2005 [12] LINAC 117 71 years (≥65 years) 18 (15%) 8 KPS ≥ 70 98%/6 months 91%/2 years 33%/6 months 60%/2 years
Kim, 2008 [13] LINAC/GK 44 79 years (≥75 years) 17 (39%) a7.3 Single BM b88% b81%
Minniti, 2013 [14] LINAC 102 77 years (≥70 years) 0 (0%) 13.2 KPS > 70, Stable extracranial disease 90%/1 year 84%/2 years 54%/1 year 78%/2 years
Watanabe, 2014 [15] GK 165 82 years (≥80 years) 4 (2%) 5.3 NR b95% NR
Park, 2015 [16] GK 147 79 years (≥70 years) 13 (9%) 5.6 KPS ≥ 90, No extracranial metastasis NR NR
Present study, 2016 GK 106 84 years (≥80 years) 0 (0%) 7.1 KPS ≥ 70, Controlled primary/no extracranial metastasis, Female sex 94%/6 months 89%/1 year 17%/6 months 25%/1 year
  1. SRS stereotactic radiosurgery, BM brain metastasis, WBRT whole brain radiotherapy, MST median survival time, LINAC linear accelerator, GK gamma knife, atime from the diagnosis, bcrude value, NR not reported