Fig. 4

Expression levels for PDEs. Expression of subtypes PDE4B and PDE5A was significantly higher in the CRN patient group. For controls in PDE5A (N = 4, n = 4), PDE4B (N = 5, n = 5), PDE4D (N = 5, n = 5). For neoplasia in PDE5A (N = 5, n = 5), PDE4B (N = 8, n = 8), PDE4D (N = 8, n = 8). Expression levels are relative to ß-actin. Data presented as means ± SEM. *p < 0.05 and **p < 0.01