Table 1 Effect of an ERβ knockdown on transcriptome of MDA-MB-231 cells as assessed by means of Affymetrix Human Gene 1.0 ST arrays. Shown are all genes exhibiting more than 2-fold change with a p-value <0.05 (n = 2)

 4,82

0,01331

CYP24A1

cytochrome P450, family 24, subfamily A, polypeptide 1

 4,23

0,00240

CXCL14

chemokine (C-X-C motif) ligand 14

 3,80

0,02136

ENC1

ectodermal-neural cortex 1 (with BTB-like domain)

 3,71

0,01270

DKK1

dickkopf 1 homolog (Xenopus laevis)

 3,38

0,00778

HIPK3

homeodomain interacting protein kinase 3

 3,36

0,02378

TRIM49B

tripartite motif containing 49B

 3,21

0,02620

MMP13

matrix metallopeptidase 13 (collagenase 3)

 3,04

0,00236

ARRDC3

arrestin domain containing 3

 2,98

0,00932

TNC

tenascin C

 2,82

0,04833

KRT4

keratin 4

 2,82

0,02350

FRG2B

FSHD region gene 2 family, member B

 2,74

0,04198

LOC100506966

uncharacterized LOC100506966

 2,72

0,00962

AQP1

aquaporin 1 (Colton blood group)

 2,62

0,01339

MFAP5

microfibrillar associated protein 5

 2,61

0,03991

ANGPT1

angiopoietin 1

 2,50

0,02567

MAPK8IP1

mitogen-activated protein kinase 8 interacting protein 1

 2,49

0,00499

DEPTOR

DEP domain containing MTOR-interacting protein

 2,48

0,04712

IGFBP5

insulin-like growth factor binding protein 5

 2,43

0,01205

NPNT

nephronectin

 2,41

0,01544

C12orf53

chromosome 12 open reading frame 53

 2,37

0,03051

HSPA2

heat shock 70 kDa protein 2

 2,36

0,02207

PLLP

plasmolipin

 2,36

0,02959

SLC47A2

solute carrier family 47, member 2

 2,35

0,01648

CRIP1

cysteine-rich protein 1 (intestinal)

 2,33

0,00857

CNIH2

cornichon homolog 2 (Drosophila)

 2,30

0,00344

TGFB2

transforming growth factor, beta 2

 2,27

0,02260

CACNG4

calcium channel, voltage-dependent, gamma subunit 4

 2,27

0,02987

CYP4F2

cytochrome P450, family 4, subfamily F, polypeptide 2

 2,26

0,02720

MTRNR2L2

MT-RNR2-like 2

 2,25

0,01804

TRIM53AP

tripartite motif containing 53A, pseudogene

 2,20

0,00819

TP53INP1

tumor protein p53 inducible nuclear protein 1

 2,19

0,02351

CLEC2L

C-type lectin domain family 2, member L

 2,19

0,00476

DRAM1

DNA-damage regulated autophagy modulator 1

 2,19

0,00903

TRIM49L1

tripartite motif containing 49-like 1

 2,19

0,00903

TRIM49L1

tripartite motif containing 49-like 1

 2,16

0,02128

PTGER4

prostaglandin E receptor 4 (subtype EP4)

 2,13

0,01616

FLRT3

fibronectin leucine rich transmembrane protein 3

 2,12

0,02280

DPYSL2

dihydropyrimidinase-like 2

 2,12

0,03376

ATP6V1B1

ATPase, H+ transporting, lysosomal 56/58 kDa, V1 subunit B1

 2,10

0,04897

FAM102B

family with sequence similarity 102, member B

 2,10

0,00007

CHST15

carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15

 2,10

0,00777

PTBP3

polypyrimidine tract binding protein 3

 2,09

0,02408

TGFB1

transforming growth factor, beta 1

 2,07

0,04539

NID1

nidogen 1

 2,07

0,03066

IGFBP7

insulin-like growth factor binding protein 7

 2,07

0,00551

LOC100509553

ETS domain-containing protein Elk-1-like

 2,05

0,03765

PPP1R3C

protein phosphatase 1, regulatory subunit 3C

 2,04

0,00619

FOXN1

forkhead box N1

 2,03

0,01322

GPR56

G protein-coupled receptor 56

 2,03

0,01062

SFN

stratifin

 2,02

0,00706

CYTL1

cytokine-like 1

 2,02

0,00298

PRICKLE1

prickle homolog 1 (Drosophila)

 2,01

0,00401

MET

met proto-oncogene (hepatocyte growth factor receptor)

 2,00

0,02964

MLLT11

myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11

 2,00

0,01646

LOX

lysyl oxidase

 −2,00

0,01776

GK5

glycerol kinase 5 (putative)

 −2,01

0,00969

KPNA5

karyopherin alpha 5 (importin alpha 6)

 −2,04

0,02721

TMC7

transmembrane channel-like 7

 −2,05

0,04973

C4orf27

chromosome 4 open reading frame 27

 −2,06

0,01484

IARS

isoleucyl-tRNA synthetase

 −2,08

0,00684

TAF9B

TAF9B RNA polymerase II, TATA box binding protein (TBP)-associated factor, 31 kDa

 −2,11

0,03884

JHDM1D

jumonji C domain containing histone demethylase 1 homolog D (S. cerevisiae)

 −2,13

0,01199

ODC1

ornithine decarboxylase 1

 −2,19

0,03799

MCMDC2

minichromosome maintenance domain containing 2

 −2,22

0,04674

GPD2

glycerol-3-phosphate dehydrogenase 2 (mitochondrial)

 −2,23

0,01299

MIR320D2

microRNA 320d-2

 −2,24

0,00323

DICER1

dicer 1, ribonuclease type III

 −2,29

0,02510

RN5S505

RNA, 5S ribosomal 505

 −2,38

0,02642

LINC00243

long intergenic non-protein coding RNA 243

 −2,55

0,04468

MTX3

metaxin 3

 −2,62

0,00555

SEMA3D

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D