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Table 4 Recurrence and breast cancer mortality in relation to BRCA status

From: Tumor characteristics and prognosis in familial breast cancer

  Person-yearsa No. of events Rate x1000 person-years (95% CI)b
DFS
 BRCA-positive 257 9 35 (16–66)
 BRCA-wild type 702 22 31 (20–47)
 Sporadic 12721 522 48 (45–53)
OS
 BRCA-positive 312 10 32 (15–59)
 BRCA-wild type 814 18 22 (13–35)
 Sporadic 14943 598 40 (37–43)
  1. The 21 patients carrying variants of unknown significance were excluded from the analysis
  2. CI confidence interval, DFS disease-free survival, OS overall survival
  3. aRates were calculated from the reference date (i.e. date of diagnosis)
  4. bConfidence interval by Haenszel et al. JNCI 1962