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Table 4 Inter-assay agreement (number of samples positive in all 3 hrHPV assays; total n = 623) for each age group and cytology classification

From: HPV Prevalence in the Dutch cervical cancer screening population (DuSC study): HPV testing using automated HC2, cobas and Aptima workflows

Age group Inter-assay agreement
% (N)
Pap class Bethesda classification Inter-assay agreement
% (N)
29–33 65.7% (180) 0 - 26.3% (5)
34–38 52.0% (105) 1 Normal 36.2% (339)
39–43 51.0% (103) 2 ASC-US 73.4% (113)
44–48 41.7% (86) 3a1 LSIL 90.8% (59)
49–53 47.7% (72) 3a2 HSIL (moderate) 95.8% (46)
54–58 29.5% (43) 3b HSIL (severe) 91.8% (56)
59–63 31.8% (34) 4 CIS/AIS 100% (5)
Total (N) 623    623
  1. Pap 0 = sample inadequate for cytology
  2. ASC-US Atypical Squamous Cells of Undetermined Significance, LSIL Low-grade Squamous Intraepithelial Lesion, HSIL High-grade Squamous Intraepithelial Lesion, CIS Carcinoma in situ, AIS Adenocarcinoma in situ