Table 2 Immune gene signatures and gene symbols
From: Conservation of immune gene signatures in solid tumors and prognostic implications
Gene signature | Gene symbol |
|---|---|
T/NK 1 | BIN2; CD3G; CD7; CD72; CTSW; CXCR6; FYB; GZMH; IKZF1; IL21R; KLRC4-KLRK1/KLRK1; KLRD1; LCK; MAP4K1; PSTPIP1; PTPN7; SIRPG; SP140; STAT4; TRAF1; UBASH3A; YME1L1; ZAP70 |
T/NK 2 | ARHGAP25; CCL5; CCR5; CD2; CD3D; CD48; CD8A; CORO1A; CST7; CXCL9; FYB; GIMAP1-GIMAP5/GIMAP5; GZMA; GZMB; GZMK; IL2RB; ITGAL; LCK; LTB; NCF1/NCF1B/NCF1C; NCF1C; NKG7; PIK3CD; PRF1; RASGRP1; SASH3; SELL; TNFAIP3; TRAC; TRAC/TRAJ17/TRAV20; TRAF3IP3; TRBC1; YME1L1 |
T/NK 3 | ACAP1; ARHGAP25; CCL19; CCR7; CD247; CD28; CD96; CRTAM; FAIM3; GPR171; GPR18; HLA-DOB; IL16; KLRB1; LAT; LRMP; MS4A1; PLCG2; PPP1R16B; PVRIG; RUNX3; SH2D1A; TRAT1; XCL1; XCL1/XCL2 |
B/P/T/NK | CD180; CD19; CD79B; CD8B/LOC100996919; CXCR3; DENND1C; FAIM3; IKZF1; IL16; ITGB7; LAT; LY9; PAX5; PLA2G2D; PRKCQ; SH2D1A; SIT1; TCL1A |
B/P | 217179_x_at; 211633_x_at; 217480_x_at; 211868_x_at; 211637_x_at; 211639_x_at; 217281_x_at; 211650_x_at; 211635_x_at; 211641_x_at; 214916_x_at; 216557_x_at; 217360_x_at; 216510_x_at; 211430_s_at; 216401_x_at; 214768_x_at; 216984_x_at; IGHD; IGHM; IGJ; IGK; IGHG1/IGHM; IGHV3-47/IGHV3-47; IGK/IGKC; IGKC; IGKV1-17/IGKV1-17; IGHA1/IGHG1/IGHM; CYAT1/IGLC1/IGLV1-44; GUSBP11; IGH/IGHA1/IGHA2; IGKV4-1/IGKV4-1; IGLC1; IGLJ3; IGLL3P; IGLL5; IGLV1-44; IGLV2-14/IGLV2-14; IGLV3-10/IGLV3-10; IGLV3-19/IGLV3-19; MZB1; PIM2; TNFRSF17; AC016745.2/OTTHUMG00000153338; |
B/M/D | 215193_x_at; 209312_x_at; 204670_x_at; CD74; HLA-DPA1; HLA-DPB1; HLA-DQB1; HLA-DRA; SLC15A3; SLC1A3; THEMIS2; TMEM140; HLA-DRB1/LOC100507709/LOC100507714; HLA-DQB1/LOC101060835; HLA-DRB6/LOC100996809 |
M/D/N 1 | APOC1; CCL18/LOC101060271; CCR1; CD300A; CD84; CD86; FCGR2C; LILRB2; LILRB4; LSP1; PILRA; SLAMF8 |
M/D/N 2 | 219574_at; AIF1; ALOX5AP; APOE; BCL2A1; C1QA; C1QB; C3AR1; C5AR1; CCL2; CCL4; CCR1; CD14; CD163; CD300A; CD53; CD86; CLEC2B; CLEC4A; CLEC7A; CSF1R; CYBB; DOCK10; DOCK2; EVI2A; EVI2B; FCER1G; FCGR1A/FCGR1B/FCGR1C; FCGR1B; FCGR2A; FCGR2B; FCGR3A/FCGR3B; FCGR3B; FGL2; GPNMB; GPR65; HCK; HCLS1; IFI30/PIK3R2; IGSF6; ITGA4; ITGB2; LAIR1; LAPTM5; LCP2; LILRB2; LST1; LY86; LY96; MNDA; MRC1; MS4A4A; MS4A6A; MSR1; MYO1F; NCF2; NCKAP1L; NPL; PILRA; PLEK; PTPRC; RGS1; RNASE6; SAMSN1; SELPLG; SLA; SLAMF8; SLC7A7; SLCO2B1; SRGN; TFEC; TLR1; TLR2; TLR7; TM6SF1; TRPV2; TYROBP; VSIG4 |
D (LPS) | B2M; CXCL10; CXCL11; DDX58; DDX60; EIF2AK2; HERC5; HERC6; HLA-B; HLA-C; HLA-G; HLA-J; IFI35; IFI44; IFI44L; IFI6; IFIH1; IFIT1; IFIT3; IFIT5; IRF7; IRF9; ISG15; LAP3; OAS1; OAS2; OAS3; PLSCR1; PSMB8; RSAD2; STAT1; TAP1; TAPBP; UBE2L6; USP18; WARS |