BMC Cancer

Table 2 Expression of Notch receptors and Hes-1 in EHCC patients

From: Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties

		Notch1				Notch2
		+	−	p	r ²	+	−	p	r ²
Total (%)		66 (50.0)	66 (50.0)			74 (56.1)	58 (43.9)
Histopathological grading	G1	5	16	0.008	0.186	10	11	0.397	0.019
Histopathological grading	G2/3	61	50			64	47
Tumor	1/2	35	32	0.259	0.089	36	31	0.584	0.067
Tumor	3/4	31	34			38	27
Node	0	46	46	1.000	0.000	49	43	0.324	0.066
Node	1	20	20			25	15
Stage	I/II	41	36	0.377	−0.086	39	38	0.776	0.123
Stage	III/IV	25	30			35	20
		Notch3				Notch4
		+	−	p	r ²	+	−	p	r ²
Total (%)		56 (42.4)	76 (57.6)			8 (6.1)	124 (93.9)
Histopathological grading	G1	5	16	0.053	0.186	0	21	0.090	0.161
Histopathological grading	G2/3	52	59			8	103
Tumor	1/2	34	33	0.049	−0.134	5	62	0.491	0.007
Tumor	3/4	22	43			3	62
Node	0	36	56	0.247	0.091	5	87	0.654	0.040
Node	1	20	20			3	37
Stage	I/II	33	44	0.929	0.013	4	73	0.624	0.049
Stage	III/IV	24	31			4	51
		Notch1-3				Hes1
		+	−	p	r ²	+	−	p	r ²
Total (%)		106 (80.3)	26 (19.7)			108 (81.8)	24 (18.2)
Histopathological grading	G1	15	6	0.283	0.056	16	4	0.951	0.022
Histopathological grading	G2/3	91	20			92	20
Tumor	1/2	52	15	0.430	0.043	54	13	0.712	0.079
Tumor	3/4	54	11			54	11
Node	0	71	21	0.156	0.119	73	19	0.371	0.097
Node	1	35	5			35	5
Stage	I/II	59	18	0.202	0.130	60	17	0.163	0.058
Stage	III/IV	47	8			48	7

P value: χ ² test
r ² value: Pearson correlation coefficient

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ISSN: 1471-2407

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