Skip to main content

Table 2 Expression of Notch receptors and Hes-1 in EHCC patients

From: Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties

  Notch1 Notch2
  + p r 2 + p r 2
Total (%) 66 (50.0) 66 (50.0)    74 (56.1) 58 (43.9)   
Histopathological grading G1 5 16 0.008 0.186 10 11 0.397 0.019
G2/3 61 50    64 47   
Tumor 1/2 35 32 0.259 0.089 36 31 0.584 0.067
3/4 31 34    38 27   
Node 0 46 46 1.000 0.000 49 43 0.324 0.066
1 20 20    25 15   
Stage I/II 41 36 0.377 −0.086 39 38 0.776 0.123
III/IV 25 30    35 20   
  Notch3 Notch4
  + p r 2 + p r 2
Total (%) 56 (42.4) 76 (57.6)    8 (6.1) 124 (93.9)   
Histopathological grading G1 5 16 0.053 0.186 0 21 0.090 0.161
G2/3 52 59    8 103   
Tumor 1/2 34 33 0.049 −0.134 5 62 0.491 0.007
3/4 22 43    3 62   
Node 0 36 56 0.247 0.091 5 87 0.654 0.040
1 20 20    3 37   
Stage I/II 33 44 0.929 0.013 4 73 0.624 0.049
III/IV 24 31    4 51   
  Notch1-3 Hes1
  + p r 2 + p r 2
Total (%) 106 (80.3) 26 (19.7)    108 (81.8) 24 (18.2)   
Histopathological grading G1 15 6 0.283 0.056 16 4 0.951 0.022
G2/3 91 20    92 20   
Tumor 1/2 52 15 0.430 0.043 54 13 0.712 0.079
3/4 54 11    54 11   
Node 0 71 21 0.156 0.119 73 19 0.371 0.097
1 35 5    35 5   
Stage I/II 59 18 0.202 0.130 60 17 0.163 0.058
III/IV 47 8    48 7   
  1. P value: χ 2 test
  2. r 2 value: Pearson correlation coefficient