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Fig. 2 | BMC Cancer

Fig. 2

From: Aberrant activation of Notch signaling in extrahepatic cholangiocarcinoma: clinicopathological features and therapeutic potential for cancer stem cell-like properties

Fig. 2

Alteration of Hes-1 expression and cell proliferation by GSI IX treatment in vitro. a qPCR. b Western blotting. Cleaved Notch1 (N1ICD) and Hes-1 expression was decreased in all cell lines treated with GSI IX, especially after exposure to 40 μM of GSI IX (a, b). c Proliferation Assay. GSI IX significantly reduced viable RBE, HuCCT1 and TFK-1 cells in a dose and time dependent manner (P < 0.05)

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BMC Cancer

ISSN: 1471-2407

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