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Table 2 Incidence densities of cancers in patients diagnosed with chronic HBV and HCV infection

From: Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in Taiwan

 

All LHID2000

 

HBV

  

HCV

 

Cancer type

Events

Ratea

Events

Ratea

IRRb

(95 % CI)

Events

Ratea

IRRb

(95 % CI)

Overall

40213

36.59

1330

94.01

2.95

(2.80–3.12)*

1232

163.00

3.33

(3.15–3.53)

Brain cancer

509

0.46

7

0.49

1.13

(0.53–2.38)

7

0.93

1.61

(0.76–3.39)

Head and neck cancer

4079

3.71

66

4.67

1.23

(0.97–1.57)

48

6.35

1.43

(1.08–1.90)*

Thyroid gland cancer

1138

1.04

24

1.70

1.78

(1.19–2.67)*

13

1.72

1.53

(0.89–2.65)

Esophageal cancer

850

0.77

15

1.06

1.45

(0.87–2.42)

11

1.46

1.48

(0.82–2.68)

Stomach cancer

2247

2.04

32

2.26

1.42

(1.00–2.01)*

37

4.90

1.78

(1.28–2.46)*

Colorectal cancer

5890

5.36

104

7.35

1.69

(1.39–2.05)*

83

10.98

1.51

(1.21–1.87)*

Liver cancer

5293

4.82

770

54.43

12.89

(11.9–13.9)*

782

103.46

16.26

(15.1–17.5)*

Gallbladder and extrahepatic bile duct cancer

501

0.46

14

0.99

2.80

(1.64–4.76)*

18

2.38

3.81

(2.38–6.10)*

Pancreatic cancer

684

0.62

19

1.34

2.73

(1.73–4.31)*

17

2.25

2.66

(1.65–4.31)*

Lung cancer

4656

4.24

74

5.23

1.57

(1.25–1.97)*

69

9.13

1.61

1.27–2.04)*

Kidney cancer

1065

0.97

28

1.98

2.47

(1.70–3.60)*

17

2.25

1.71

(1.06–2.76)*

Bladder cancer

1324

1.20

24

1.70

1.83

(1.22–2.74)*

24

3.18

1.98

(1.33–2.97)*

Uterine and corpus cancerc

600

1.10

14

2.29

2.12

(1.25–3.61)*

11

2.98

2.17

(1.19–3.93)*

Cervical cancerc

1877

3.43

10

1.64

0.51

(0.27–0.95)

11

2.98

0.62

(0.34–1.12)

Ovarian cancerc

592

1.08

15

2.45

2.29

(1.37–3.82)*

8

2.16

1.67

(0.83–3.35)

Prostate cancerd

1820

3.30

30

3.73

1.83

(1.28–2.63)*

24

6.21

1.55

(1.04–2.32)*

Breast cancerc

4695

8.58

74

12.10

1.43

(1.14–1.80)*

46

12.45

1.17

(0.87–1.56)

Melanoma

136

0.12

0

--

--

--

2

0.26

1.58

(0.39–6.37)

Skin cancer

619

0.56

15

1.06

2.44

(1.46–4.08)*

11

1.46

1.90

(1.04–3.44)*

Non-Hodgkin’s lymphoma

738

0.67

22

1.56

2.58

(1.69–3.94)*

20

2.65

3.01

(1.93–4.69)*

Myeloma

218

0.20

2

0.14

0.87

(0.22–3.49)

3

0.40

1.47

(0.47–4.60)

Leukemia

682

0.62

15

1.06

1.82

(1.09–3.04)*

7

0.93

1.19

(0.56–2.50)

  1. IRR incidence rate ratio
  2. aPer 10,000 person-years
  3. bAdjusted for sex and age
  4. cWomen only
  5. dMen only
  6. *p< 0.05