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Table 2 Incidence densities of cancers in patients diagnosed with chronic HBV and HCV infection

From: Chronic hepatitis infection is associated with extrahepatic cancer development: a nationwide population-based study in Taiwan

  All LHID2000   HBV    HCV  
Cancer type Events Ratea Events Ratea IRRb (95 % CI) Events Ratea IRRb (95 % CI)
Overall 40213 36.59 1330 94.01 2.95 (2.80–3.12)* 1232 163.00 3.33 (3.15–3.53)
Brain cancer 509 0.46 7 0.49 1.13 (0.53–2.38) 7 0.93 1.61 (0.76–3.39)
Head and neck cancer 4079 3.71 66 4.67 1.23 (0.97–1.57) 48 6.35 1.43 (1.08–1.90)*
Thyroid gland cancer 1138 1.04 24 1.70 1.78 (1.19–2.67)* 13 1.72 1.53 (0.89–2.65)
Esophageal cancer 850 0.77 15 1.06 1.45 (0.87–2.42) 11 1.46 1.48 (0.82–2.68)
Stomach cancer 2247 2.04 32 2.26 1.42 (1.00–2.01)* 37 4.90 1.78 (1.28–2.46)*
Colorectal cancer 5890 5.36 104 7.35 1.69 (1.39–2.05)* 83 10.98 1.51 (1.21–1.87)*
Liver cancer 5293 4.82 770 54.43 12.89 (11.9–13.9)* 782 103.46 16.26 (15.1–17.5)*
Gallbladder and extrahepatic bile duct cancer 501 0.46 14 0.99 2.80 (1.64–4.76)* 18 2.38 3.81 (2.38–6.10)*
Pancreatic cancer 684 0.62 19 1.34 2.73 (1.73–4.31)* 17 2.25 2.66 (1.65–4.31)*
Lung cancer 4656 4.24 74 5.23 1.57 (1.25–1.97)* 69 9.13 1.61 1.27–2.04)*
Kidney cancer 1065 0.97 28 1.98 2.47 (1.70–3.60)* 17 2.25 1.71 (1.06–2.76)*
Bladder cancer 1324 1.20 24 1.70 1.83 (1.22–2.74)* 24 3.18 1.98 (1.33–2.97)*
Uterine and corpus cancerc 600 1.10 14 2.29 2.12 (1.25–3.61)* 11 2.98 2.17 (1.19–3.93)*
Cervical cancerc 1877 3.43 10 1.64 0.51 (0.27–0.95) 11 2.98 0.62 (0.34–1.12)
Ovarian cancerc 592 1.08 15 2.45 2.29 (1.37–3.82)* 8 2.16 1.67 (0.83–3.35)
Prostate cancerd 1820 3.30 30 3.73 1.83 (1.28–2.63)* 24 6.21 1.55 (1.04–2.32)*
Breast cancerc 4695 8.58 74 12.10 1.43 (1.14–1.80)* 46 12.45 1.17 (0.87–1.56)
Melanoma 136 0.12 0 -- -- -- 2 0.26 1.58 (0.39–6.37)
Skin cancer 619 0.56 15 1.06 2.44 (1.46–4.08)* 11 1.46 1.90 (1.04–3.44)*
Non-Hodgkin’s lymphoma 738 0.67 22 1.56 2.58 (1.69–3.94)* 20 2.65 3.01 (1.93–4.69)*
Myeloma 218 0.20 2 0.14 0.87 (0.22–3.49) 3 0.40 1.47 (0.47–4.60)
Leukemia 682 0.62 15 1.06 1.82 (1.09–3.04)* 7 0.93 1.19 (0.56–2.50)
  1. IRR incidence rate ratio
  2. aPer 10,000 person-years
  3. bAdjusted for sex and age
  4. cWomen only
  5. dMen only
  6. *p< 0.05
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