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Fig. 6 | BMC Cancer

Fig. 6

From: Let-7 inhibits self-renewal of hepatocellular cancer stem-like cells through regulating the epithelial-mesenchymal transition and the Wnt signaling pathway

Fig. 6

Let-7a sensitized HCC stem-like cells to cis-platinum induced self-renewal inhibition. a. Cis-platinum reduced sphere number through inhibition of Wnt1 expression. b. The combined use of cis-platinum and let-7a significantly decreased the sphere number, inhibiting the self-renewal ability of HCC stem-like cells through concurrent effects on Wnt signaling. c. Both let-7a and cis-platinum inhibited Wnt1 explression level, and exerted sygnergic inhibition on Wnt1 activity

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BMC Cancer

ISSN: 1471-2407

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