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Table 3 Univariate and multivariate analyses of factors associated with survival and recurrence

From: High-mobility group protein box1 expression correlates with peritumoral macrophage infiltration and unfavorable prognosis in patients with hepatocellular carcinoma and cirrhosis

  OS RFS
  P* Multivariate P* Multivariate
   HR(95 %) P   HR(95 %) P
Age, y 0.855 NA NA 0.976 NA NA
Gender, male/female 0.852 NA NA 0.572 NA NA
a-Fetoprotein >400 vs. ≤ 200 ng/dL 0.209 NA NA 0.064 NA NA
Tumor size, >5 vs. ≤ 5 cm 0.005 1.699(1.203-2.685) 0.038 0.016 1.478(0.856-2.554) 0.161
Encapsulation complete vs. none 0.735 NA NA 0.942 NA NA
Tumor differentiation, III–IV vs. I–II 0.026 1.217(0.715-2.072) 0.468 0.015 1.157(1.103-2.584) 0.026
BCLC stage, C vs. B vs. A 0.003 1.783(1.265-2.564) 0.027 0.003 1.768(0.949-3.295) 0.073
Recurrence, yes vs. no 0.062 NA NA 0.052 NA NA
Peritumoral HMGB1, high vs. low 0.001 1.872(1.148-3.053) 0.009 0.002 1.697(1.035-2.783) 0.014
Intratumoral HMGB1, high vs. low 0.028 1.270(0.745-2.166) 0.462 0.060 NA NA
Peritumoral CD68, high vs. low 0.017 1.567(1.058-2.563) 0.039 0.026 1.532(1.127-2.531) 0.037
Intratumoral CD68, high vs. low 0.952 NA NA 0.823 NA NA
  1. Abbreviations: y year, BCLC Barcelona clinic liver cancer, NA not adopted
  2. *Univariate analysis