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Table 2 Methodology and quality of inclined studies

From: Increased serum amyloid A as potential diagnostic marker for lung cancer: a meta-analysis based on nine studies

Authors

Year

Research design

Country

Asians/Caucasians

Test method

Measurement units

QUADAS

Benson MD [12]

1986

Prospective

Indiana

0/100

Competitive binding radioimmunoassay

u/ml

12

Howard BA [13]

2003

Retrospective

USA

0/19

ELISA

ng/mL

7

Khan N [14]

2004

NA

North Carolina

0/50

MALDI-TOF; ELISA

ng/mL

10

Dai S [16]

2007

Retrospective

China

175/0

SELDI-TOF-MS; ELISA

Peak intensities

9

Liu DH [17]

2007

NA

China

275/0

Protein Chip Array

Peak intensities

10

Cho WC [15]

2010

Retrospective

Hong Kong

189/0

SELDI-TOF; quantitative analysis

Peak intensities; ug/mL−1

11

Sung HJ [4]

2011

Retrospective

South Korea

380/0

LC-ESI-MS/MS Analysis; ELISA

ug/mL

12

Dowling P [18]

2011

Retrospective

Ireland

0/109

ELISA

ug/mL

10

Kanoh Y [9]

2013

NA

Japan

37/0

Latex nephelometry

ug/mL

7

  1. QUADAS quality assessment for studies of diagnostic accuracy (maximum score 14); ELISA enzyme-linked immunosorbent assays; MALDI-TOF matrix assisted laser desorption ionization time of flight; SELDI-TOF-MS surface-enhanced laser desorption/inionation-time of flight-mass spectra; LC-ESI-MS/MS liquid chromatography-electrospray ionisation-tandem mass spectrometry NA unavailable