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Fig. 1 | BMC Cancer

Fig. 1

From: Molecular features of the cytotoxicity of an NHE inhibitor: Evidence of mitochondrial alterations, ROS overproduction and DNA damage

Fig. 1

HMA affects cell morphology and mitochondria distribution. a TEM (transmission electron microscopy) analysis of diaminobenzidine (DAB) photo-oxidation in HCT-116 untreated cells and in cells treated with 20 μM HMA for 24 h. Red asterisk marks vesicles enclosing electron-dense regions within the cytoplasm; red arrowheads refer to vesicles containing intracellular debris. b Bright field microscopy images of HCT-116 cells untreated and treated with 20 μM HMA for 24 h; nuclei are marked with *. c Immunofluorescence analysis of mitochondrial HSP70 in untreated and HMA-treated (20 μM for 24 h) HCT-116 cells. Scale bar: 50 μm. A representative experiment out of three is shown

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BMC Cancer

ISSN: 1471-2407

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