Table 1 Characteristics of patients with wild-type or mutant HER-2 and positive or negative HER-2 expression by immunohistochemistry
From: Epidemiological study of HER-2 mutations among EGFR wild-type lung adenocarcinoma patients in China
HER-2 WT n(%) | HER-2 MUT n(%) | p value | HER-2 IHC(-) n(%) | HER-2 IHC(+) n(%) | p value | ||
|---|---|---|---|---|---|---|---|
Sex | Male | 239(55.1) | 11(50.0) | 0.666 | 162(53.6) | 30(54.5) | 1.000 |
Female | 195(44.9) | 11(50.0) | 140(46.4) | 25(45.5) | |||
Age | ≥65 | 132(30.4) | 3(13.6) | 0.100 | 80(26.5) | 21(38.2) | 0.103 |
<65 | 302(69.6) | 19(86.4) | 222(73.5) | 34(61.8) | |||
Smoking status | Never/light smoking | 280(64.5) | 15(68.2) | 0.822 | 190(62.9) | 40(72.7) | 0.172 |
Smoking | 154(35.5) | 7(31.8) | 112(37.1) | 15(27.3) | |||
Disease stage | I | 249(62.3) | 13(59.1) | 0.619 | 184(66.9) | 31(62.0) | 0.887 |
II | 43(10.8) | 3(13.6) | 27(9.8) | 5(10.0) | |||
III | 85(21.3) | 6(27.3) | 52(18.9) | 12(24.0) | |||
IV | 23(5.8) | 0(0.0) | 12(4.4) | 2(4.0) | |||
Histologic subtype | Lepidic | 40(9.6) | 0(0.0) | 0.436 | 34(11.5) | 3(5.8) | 0.166 |
Acinar | 179(43.1) | 8(36.4) | 126(42.7) | 20(38.5) | |||
Papillary | 92(22.2) | 8(36.4) | 57(19.3) | 12(23.1) | |||
Micropapillary | 14(3.4) | 0(0.0) | 12(4.1) | 1(1.9) | |||
Solid | 33(8.0) | 2(9.1) | 20(6.8) | 8(15.4) | |||
IMA | 28(6.7) | 3(13.6) | 24(8.1) | 4(7.7) | |||
Enteric | 2(0.5) | 0(0.0) | 1(0.3) | 1(0.2) | |||
AIS | 14(3.4) | 0(0.0) | 12(4.1) | 0(0.0) | |||
MIA | 13(3.1) | 1(4.5) | 9(3.1) | 3(5.8) | |||