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Table 1 Concentration versus activity of ozonide antimalarials and artemisinin in BE (2)-c and IMR-32 neuroblastoma and Ewing’s Sarcoma. IC50 calculated from concentration versus absorbance (response) graph with concentrations of 0, 0.5, 1, 2.5, 5, and 10 mcg/ml. Ten measurements were obtained at each concentration. All drugs and control were in 0.01 % DMSO and growth media

From: Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513

  Compound IC50 (mcg/ml) BE (2)-c IC50 (mcg/ml) IMR-32 IC50 (mcg/ml) EWS A673
1 OZ323 6.0 6.1 6.2
2 OZ375 5.8 3.9 >10
3 OZ418 >10 >10 >10
4 OZ401 >10 >10 >10
5 OZ465 >10 >10 >10
6 OZ78 >10 4.5 >10
7 OZ439 >10 5.6 >10
8 OZ277 >10 >10 >10
9 OZ521 1.4 >10 5.8
10 OZ493 2.2 >10 6.9
11 OZ417 >10 3.4 >10
12 OZ513 0.5 3.1 3.3
13 DHA 3.2 >10 NT
14 ART >10 NT NT
15 AS >10 NT NT