Table 1 Concentration versus activity of ozonide antimalarials and artemisinin in BE (2)-c and IMR-32 neuroblastoma and Ewing’s Sarcoma. IC50 calculated from concentration versus absorbance (response) graph with concentrations of 0, 0.5, 1, 2.5, 5, and 10 mcg/ml. Ten measurements were obtained at each concentration. All drugs and control were in 0.01 % DMSO and growth media
From: Treatment of a chemoresistant neuroblastoma cell line with the antimalarial ozonide OZ513
| Â | Compound | IC50 (mcg/ml) BE (2)-c | IC50 (mcg/ml) IMR-32 | IC50 (mcg/ml) EWS A673 |
|---|---|---|---|---|
1 | OZ323 | 6.0 | 6.1 | 6.2 |
2 | OZ375 | 5.8 | 3.9 | >10 |
3 | OZ418 | >10 | >10 | >10 |
4 | OZ401 | >10 | >10 | >10 |
5 | OZ465 | >10 | >10 | >10 |
6 | OZ78 | >10 | 4.5 | >10 |
7 | OZ439 | >10 | 5.6 | >10 |
8 | OZ277 | >10 | >10 | >10 |
9 | OZ521 | 1.4 | >10 | 5.8 |
10 | OZ493 | 2.2 | >10 | 6.9 |
11 | OZ417 | >10 | 3.4 | >10 |
12 | OZ513 | 0.5 | 3.1 | 3.3 |
13 | DHA | 3.2 | >10 | NT |
14 | ART | >10 | NT | NT |
15 | AS | >10 | NT | NT |