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Table 2 Univariate analysis of pre-operative, tumoral post-operative, therapeutic post operative and lymphopenia parameters for association with Overall Survival (N = 390)

From: Additive value of pre-operative and one-month post-operative lymphocyte count for death-risk stratification in patients with resectable pancreatic cancer: a multicentric study

   Number of patients Number of Deaths  
HR 95 % CIa P
Pre-operative parameters Age at surgery — years
  ≤ 65 174 130 1   
  > 65 216 179 1.405 [1.120; 1.764] 0.0034
Patient sex
 Male 222 169 1   
 Female 168 140 1.224 [0.978; 1.533] 0.0769
Diabetes
 No 252 199 1   
 Yes 73 61 1.188 [0.891; 1.584] 0.2416
Albuminemia 191 154 0.973 [0.953; 0.993] 0.0089
Tumor Size in cm 301 233 1.011 [0.931; 1.099] 0.7899
Post-operative tumoral parameters pT Local invasion
 0-1-2 39 27 1   
 3–4 336 270 1.331 [0.895; 1.980] 0.1575
N status
 0 119 89    
 1 269 218 1.148 [0.897; 1.470] 0.2740
Lymph Nodes ratio
  < 0.2 279 205    
  ≥ 0.2 104 96 1.759 [1.373; 2.252] <0.0001
Positive lymp nodes ratio (N+/Total number of lymph nodes) 380 300 3.308 [1.962; 5.577] <0.0001
Histological Grade
 Poorly differentiated 85 67 1   
 Moderately differentiated 158 127 0.797 [0.592; 1.072]  
 Well differentiated 88 64 0.672 [0.476; 0.947] 0.0735
Vascular invasion
 No 242 179 1   
 Yes 119 102 1.437 [1.125; 1.836] 0.0037
Lymphatic invasion
 No 230 174 1   
 Yes 134 110 1.199 [0.944; 1.524] 0.1374
Perineural invasion
 No 138 103 1   
 Yes 227 183 1.172 [0.920; 1.493] 0.1989
Therapeutic post-operative parameter Adjuvant Chemotherapy— no. (%)
 No 85 73 1   
 Yes 251 194 0.505 [0.385; 0.663] <0.0001
Lymphopenia parameters Pre-operative lymphocyte count 390 309 0.692 [0.546; 0.877] 0.0023
Post-operative lymphocyte count 301 225 0.674 [0.508; 0.895] 0.0065
Pre-operative lymphocyte count
  ≤ 1000 110 98 1   
  > 1000 280 211 0.693 [0.545; 0.881] 0.0028
Post-operative lymphocyte count
  ≤ 1000 65 56 1   
  > 1000 236 169 0.485 [0.356; 0.660] <0.0001
Pre and post-operative lymphocyte count category
  > 1000/>1000 182 123 1   
  ≤ 1000/>1000 54 46 1.486 [1.058; 2.088]  
  > 1000/≤1000 37 30 2.213 [1.476; 3.317]  
  ≤ 1000/≤1000 28 26 2.340 [1.524; 3.593] <0.0001
  1. Abbreviations: HR hazard ratio, pT histologic tumoral invasion, Nstatus lymph node status, F-up follow-up, Nratio lymph node ratio (Number of positive lymph nodes/Total number of lymph nodes
  2. aCI denotes confidence interval