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Table 1 Baseline characteristics of the overall population and according to the two cohort sets

From: Additive value of pre-operative and one-month post-operative lymphocyte count for death-risk stratification in patients with resectable pancreatic cancer: a multicentric study

  Patients Characteristics Overall population (N =390) Cohort set 1 (N =192) Cohort set 2 (N =198) P
  N   N   N   
Pre-operative parameters Age at surgery — years 390   192   198   
   ≤ 65   174 (45 %)   87 (45 %)   87 (44 %)  
   > 65   216 (55 %)   105 (55 %)   111 (56 %) 0.8387
Patient male sex — no. (%) 390 222 (57 %) 192 103 (54 %) 198 119 (60 %) 0.2201
Diabetes — no. (%) 325   186   139   
 No   252 (78 %)   143 (77 %)   109 (78 %)  
 Yes   73 (22 %)   43 (23 %)   30 (22 %) 0.7891
Albuminemia g/L 191 36.4 ± 7.7 70 32.6 ± 6.4 121 38.6 ± 7.4 <0.0001
Tumor Size in cm 301 3.8 ± 1.6 164 3.6 ± 1.5 137 4.0 ± 1.6 0.0095
Tumoral post-operative parameters pT Local invasion — no. (%) 375   184   193   
 0-1-2   39 (10 %)   28 (15 %)   11 (6 %)  
 3–4   336 (90 %)   154 (85 %)   182 (94 %) 0.0022
N status 388   190   198   
 0   119 (31 %)   68 (36 %)   51 (26 %)  
 1   269 (69 %)   122 (64 %)   147 (74 %) 0.0365
Positive lymph nodes ratio 380 0.15 ± 0.19 182 0.20 ± 0.23 198 0.12 ± 0.14 <0.0001
Lymph Nodes ratio
  < 0.2 380 279 (73 %)   117 (64 %)   162 (81 %)  
  ≥ 0.2   104 (27 %)   67 (36 %)   37 (19 %) <0.0001
Histological Grade 331   160   171   
 Poorly differentiated   85 (26 %)   23 (14 %)   62 (36 %)  
 Moderately differentiated   158 (48 %)   76 (48 %)   82 (48 %)  
 Well differentiated   88 (26 %)   61 (38 %)   27 (16 %) <0.0001
Vascular invasion 361   186   175   
 No   242 (67 %)   115 (62 %)   127 (73 %)  
 Yes   119 (33 %)   71 (38 %)   48 (27 %) 0.0335
Lymphatic invasion 364   189   175   
 No   230 (63 %)   107 (57 %)   123 (70 %)  
 Yes   134 (37 %)   82 (43 %)   52 (30 %) 0.0089
Perineural invasion 365   191   174   
 No   138 (38 %)   57 (30 %)   81 (47 %)  
 Yes   227 (62 %)   134 (70 %)   93 (53 %) 0.0012
Therapeutic post-operative parameter Adjuvant Chemotherapy 336 251 (75 %) 183 118 (64 %) 153 133 (87 %) <0.0001
Lymphopenia parameters Pre-operative lymphocyte counta 390 1458.9 (150–8350) 194 1492.1 (170–3052) 199 1426 (150–8350) 0.3362
Post-operative lymphocyte counta 299 1410 (200–32000) 127 1400 (251–3620) 172 1430 (200–32000) 0.2657
Follow-up parameters Death events 393 309 (79 %) 192 157 (82 %) 198 152 (77 %) 0.2233
Median F-up time in months 95 % CIb   66.6 (60.8–78.7)   66.6 (58.0–84.0)   67.2 (56.2–79.0)  
  1. Abbreviations: pT histologic tumoral invasion, Nstatus lymph node status, F-up follow-up, lymph node ratio (Number of positive lymph nodes/Total number of lymph nodes)
  2. amedian (min-max) were reported for lymphocyte count due to their skewed distribution
  3. bCI denotes confidence interval
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BMC Cancer

ISSN: 1471-2407

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