Incidence and Survival of urothelial carcinoma of the urinary bladder in Norway 1981-2014

Andreassen, B. K.; Aagnes, B.; Gislefoss, R.; Andreassen, M.; Wahlqvist, R.

doi:10.1186/s12885-016-2832-x

BMC Cancer

Table 3 Incidence rates

From: Incidence and Survival of urothelial carcinoma of the urinary bladder in Norway 1981-2014

		1981-1985	1986-1990	1991-1995	1996-2000	2001-2005	2006-2010	2011-2014	β _I (SE)	p-value
Men	n	2972	3321	3628	3575	3928	4192	3915
		18.5	19.7	21.1	19.7	20.6	20.4	21.4	0.070(0.021)	0.002^a
Women	n	974	1038	1110	1150	1262	1380	1316
		4.7	4.9	5.2	5.1	5.3	5.7	6.2	0.043(0.007)	5.9E-07^a
Men	Age (years)
	0–49	2.0	1.8	2.1	2.0	1.9	1.8	2.5	0.008(0.007)	0.246
	50–64	46.2	49.0	50.4	40.3	42.4	42.6	44.4	−0.196(0.102)	0.065
	65–79	148.4	156.0	171.0	169.1	175.4	176.1	173.1	0.899(0.186)	3.2E-05^a
	80+	194.1	256.2	263.1	268.0	301.8	286.1	317.8	3.47(0.45)	7.1E-09^a
	Morphology
	Non-inv pap carcinoma LG	8.7	9.5	9.9	9.2	9.5	8.9	8.3	−0.016(0.016)	0.335
	Non-inv pap carcinoma HG	0.6	0.9	1.3	0.9	1.4	2.3	2.6	0.061(0.006)	1.5E-10^a
	Dysplasia	0.6	0.7	1.0	0.9	0.6	0.6	1.4	0.011(0.006)	0.070
	Carcinoma in situ	0.4	0.7	0.7	0.9	0.9	0.9	0.7	0.013(0.003)	0.002^a
	Inv carcinoma	8.2	8.0	8.2	7.8	8.2	7.7	8.4	−0.001(0.010)	0.985
	Stage
	Localised	16.6	17.9	19.6	18.2	18.6	18.5	19.9	0.072(0.021)	0.001^a
	Regional advanced	1.3	1.1	1.0	0.8	1.3	1.4	1.0	0.001(0.005)	0.919
	Distant advanced	0.6	0.7	0.5	0.7	0.7	0.6	0.4	−0.003(0.003)	0.380
Women	Age (years)
	0–49	0.7	0.7	0.8	0.7	0.6	0.7	0.8	0.001(0.004)	0.739
	50–64	12.3	13.0	12.8	11.6	13.8	14.1	15.0	0.083(0.034)	0.021^a
	65–79	34.2	35.7	39.2	41.3	41.2	44.8	47.5	0.425(0.061)	6.4E-08^a
	80+	57.0	52.9	50.8	52.3	61.2	61.4	76.3	0.519(0.167)	0.004^a
	Morphology
	Non-inv pap carcinoma LG	2.1	2.4	2.4	2.5	2.8	2.8	2.6	0.022(0.005)	1.0E-04^a
	Non-inv pap carcinoma HG	0.1	0.1	0.3	0.2	0.2	0.4	0.6	0.014(0.002)	5.4E-08^a
	Dysplasia	0.2	0.2	0.2	0.2	0.2	0.2	0.6	0.006(0.003)	0.037^a
	Carcinoma in situ	0.1	0.2	0.1	0.2	0.2	0.2	0.1	0.002(0.001)	0.233
	Inv carcinoma	2.3	2.0	2.2	1.9	2.0	2.1	2.3	−0.001(0.005)	0.823
	Stage
	Localised	4.2	4.4	4.7	4.5	4.7	5.0	5.7	0.040(0.008)	8.6E-06^a
	Regional advanced	0.4	0.3	0.2	0.3	0.4	0.4	0.3	0.001(0.001)	0.611
	Distant advanced	0.2	0.2	0.2	0.2	0.2	0.3	0.2	0.002(0.001)	0.172

Age-standardized incidence rates (applying the World Standard Population) by sex, morphology group and stage as well as age-specific incidence rates stratified for 5-years interval of diagnosis from 1981 to 2014. Average annual incidence changes \( \left({\widehat{\beta}}_I\right) \) are reported together with standard error (SE) and the p-value for the test of a significant incidence trend. Significant p-values (based on the 5 % threshold) are marked with^a

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