Fig. 7

CPS slowed the growth of 786-O xenografts in vivo. a and b CPS suppressed the growth of 786-O xenografts in nude mice models by tumor volume (a) and tumor weight (b). c Tumor sections were immunostained for PCNA (top panels) and Ki-67 to assess cell proliferation (medium panels), and stained with TUNEL to assess the apoptosis rate (bottom panels). d, e and f Quantitation of PCNA , Ki-67 and TUNEL positive cells indicated that the administration of CPS reduced cell proliferation and increased apoptosis in 786-O tumors in vivo, relative to controls. The data are presented as mean ± SD. *P < 0.05, ** P < 0.01, ***P < 0.001; bars, SD. One-Way ANOVA was used for the data analysis