Table 2 KEGG pathway enrichment analysis of genes differently expressed in LLC1 cells between 2D and lr-ECM 3D cell culture conditions
Category groups | All | Up-regulated | Down-regulated | |||
|---|---|---|---|---|---|---|
Genes | p value | Genes | p value | Genes | p value | |
Metabolic pathways | ||||||
Metabolic pathways | 73 | 2.83e–13 | 30 | 7.55e–06 | 43 | 2.02e–08 |
MAP Kinase | ||||||
MAPK signaling pathway | 25 | 6.23e–08 | 11 | 0.0010 | 14 | 0.0002 |
Cell adhesion | ||||||
Regulation of actin cytoskeleton | 20 | 1.35e–06 | 6 | 0.0404 | 14 | 3.76e–05 |
Focal adhesion | 17 | 3.33e–05 | 7 | 0.0148 | 10 | 0.0018 |
Cell adhesion molecules (CAMs) | 10 | 0.0062 | 5 | 0.0368 | 5 | NS |
Gap junction | 7 | 0.0103 | 2 | NS | 5 | 0.0174 |
Tight junction | 9 | 0.0103 | 5 | NS | 4 | NS |
ECM-receptor interaction | 6 | 0.0237 | 4 | 0.0257 | 2 | NS |
Immune response | ||||||
Cytokine-cytokine receptor interaction | 18 | 0.0001 | 6 | NS | 12 | 0.0011 |
T cell receptor signaling pathway | 11 | 0.0003 | 3 | NS | 8 | 0.0011 |
VEGF signaling pathway | 9 | 0.0004 | 5 | 0.0062 | 4 | NS |
Cytosolic DNA–sensing pathway | 7 | 0.0013 | 4 | 0.0111 | 3 | NS |
B cell receptor signaling pathway | 7 | 0.0058 | 3 | NS | 4 | NS |
RIG-I-like receptor signaling pathway | 6 | 0.0121 | 5 | 0.0045 | 1 | NS |
Natural killer cell mediated cytotoxicity | 8 | 0.0153 | 3 | NS | 5 | 0.0435 |
Jak–STAT signaling pathway | 9 | 0.0159 | 3 | NS | 6 | 0.0336 |
Fc epsilon RI signaling pathway | 6 | 0.0186 | 2 | NS | 4 | NS |
Chemokine signaling pathway | 9 | 0.0362 | 3 | NS | 6 | NS |
Toll-like receptor signaling pathway | 5 | 0.0401 | 4 | NS | 2 | NS |