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Fig. 6 | BMC Cancer

Fig. 6

From: The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells

Fig. 6

APC protein and sequencing chromatography results. a The APC protein scheme with the MCR and hot spot regions marked in red and sequenced area marked in black. b Sequencing results of the APC gene and the hot spots in genomic DNA extracted from FAP1 and FAP2 hESC lines at different passages. c Sequencing of codon 1317 region in the MCR of genomic DNA extracted from FAP1 cells at high passage (p53) as well as from both of the embryo donors (both maternal and paternal DNA). The mother has one WT allele that is altered to C in the second allele. The embryo inherited the mutated C allele from her mother and the WT G allele from the father

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