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Fig. 2 | BMC Cancer

Fig. 2

From: The effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells

Fig. 2

Confirmation of the APC germline mutation in FAP1 hESCs. a The mutation (R332X) and 3 polymorphic markers flanking the mutation area (D5S941, D5S3463, D5S529) for showing that the FAP1 cells, indeed, inherited the mutated APC allele from the affected father (mutated allele in red, normal allele in black). b DNA sequencing of the mutation area showing a thymine (red arrow, R332X mutation) instead of cytosine (normal allele) and resulting in a stop codon

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