Polymorphisms in the estrogen receptor alpha gene (ESR1), daily cycling estrogen and mammographic density phenotypes.

Table 2 The linear association between the selected SNPs in the ESR1 region and percent mammographic density

SNPs	BMI variable	β-value	95 % CI^a	P-value
rs3020364	Ungrouped^b	−3.86	(−6.78, −0.95)	0.010
	BMI median split^c
	Low	−6.17	(−11.1, −1.29)	0.014
	High	−3.61	(−7.40, 0.18)	0.062
rs2474148	Ungrouped^b	−3.37	(−6.26, −0.48)	0.023
	BMI median split^c
	Low	−4.10	(−9.04, 0.85)	0.103
	High	−4.60	(−8.32, −0.89)	0.016
rs12154178	Ungrouped^b	−3.27	(−6.15, −0.39)	0.026
	BMI median split^c
	Low	−5.93	(−19.6, −1.29)	0.013
	High	−3.29	(−7.02, 0.45)	0.084
rs2347867	Ungrouped^b	−4.24	(−6.97, −1.52)	0.002
	BMI median split^c
	Low	−5.94	(−10.2, −1.71)	0.006
	High	−4.34	(−8.09, −0.60)	0.024
rs6927072	Ungrouped^b	−3.77	(−6.48, −1.06)	0.007
	BMI median split^c
	Low	−5.57	(−9.87, −1.24)	0.012
	High	−4.30	(−7.95, −0.65)	0.022
rs2982712	Ungrouped^b	−3.89	(−6.67, −1.11)	0.006
	BMI median split^c
	Low	−6.18	(−10.7, −1.62)	0.008
	High	−3.02	(−6.69, 0.64)	0.104
rs3020407	Ungrouped^b	−3.25	(−5.98, −0.51)	0.020
	BMI median split^c
	Low	−5.23	(−9.55, −0.91)	0.180
	High	−3.27	(−6.91, 0.37)	0.078
rs9322335	Ungrouped^b	−3.46	(−6.46, −0.46)	0.24
	BMI median split^c
	Low	−5.61	(−10.5, −0.73)	0.025
	High	−2.71	(−6.70, 1.29)	0.182

^aConfidence Interval
^bMultivariable linear regression, adjusted by age, BMI, age at menarche and parity
^cMultivariable linear regression, adjusted by age, age at menarche and parity. BMI median split at 23.64 kg/m²
^cOnly Single Nucleotide Polymorphisms (SNPs) with one or more two-tailed p-values < 0.05 represented (8/34 selected SNPs with Minor allele frequency (MAF) > 0.2)

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