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Fig. 4 | BMC Cancer

Fig. 4

From: Natural history of superficial head and neck squamous cell carcinoma under scheduled follow-up endoscopic observation with narrow band imaging: retrospective cohort study

Fig. 4

Endoscopic and pathological imaging of a progression lesion. a Brownish area with irregular IPCL in left pyriform sinus at diagnosis. The diameter was 5 mm. b The photomicrograph of the biopsy specimen shows the histopathology of squamous cell carcinoma in situ. (Hematoxylin and eosin staining × 20). c After 24 months. The lesion was not significantly different. d After 40 months. The lesion enlarged to 20 mm in diameter. e After 48 months. The lesion was larger and elevated. f After 58 months. An irregular surface and thickness of the lesion appeared. Submucosa invasion was suspected

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