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Fig. 3 | BMC Cancer

Fig. 3

From: Depletion of γ-glutamylcyclotransferase inhibits breast cancer cell growth via cellular senescence induction mediated by CDK inhibitor upregulation

Fig. 3

Induction of senescence by GGCT knockdown depends on p21WAF1/CIP1 upregulation in MCF7 cells. a-b The expression levels of p21WAF1/CIP1 (a) mRNA and (b) protein in MCF7 cells harvested 4 days after transfection with the indicated siRNAs were analyzed by qRT-PCR and western blotting, respectively. c Representative images of SA-β-Gal staining 4 days after transfection with the indicated siRNAs in MCF7 and MDA231-MB cells. Scale bar represents 50 μm. d The numbers of SA-β-Gal positive cells were counted and their ratios in total cells are shown. (** p < 0.01)

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BMC Cancer

ISSN: 1471-2407

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