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Table 3 Heterogeneity of c-MYC and ß-catenin with respect to tumor location in advanced CRC (cohort 2)

From: Favorable prognosis in colorectal cancer patients with co-expression of c-MYC and ß-catenin

cMYC IHC Distant metastasis LN metastasis
Negative Positive Negative Positive
Primary Negative 52 (29.5 %) 22 (12.5 %) 23 (20.7 %) 21 (18.9 %)
  Positive 58 (33.0 %) 44 (25.0 %) 14 (12.6 %) 53 (47.7 %)
cMYC mRNA ISH Distant metastasis LN metastasis
Negative Positive Negative Positive
Primary Negative 19 (10.8 %) 20 (11.4 %) 8 (7.2 %) 17 (15.3 %)
Positive 25 (14.2 %) 112 (63.6 %) 17 (15.3 %) 69 (62.2 %)
ß-catenin IHC Distant metastasis LN metastasis
Negative Positive Negative Positive
Primary Negative 55 (31.3 %) 14 (8.0 %) 30 (27.0 %) 13 (11.7 %)
Positive 37 (21.0 %) 70 (39.8 %) 16 (14.4 %) 52 (46.8 %)
  1. Abbreviations: IHC immunohistochemistry, ISH in-situ hybridization