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Table 2 Radiotherapy dose escalation levels

From: A phase-I trial of pre‐operative, margin intensive, stereotactic body radiation therapy for pancreatic cancer: the ‘SPARC’ trial protocol

Radiotherapy dose level Tumour (PTV) Area at risk of R1 (PTV_R)
Dose/# [Gy] Total dose [Gy] *BED [Gy10] EQD2 [Gy] Dose/# [Gy] Total dose [Gy] *BED [Gy10] EQD2 [Gy]
Level −1 6 30 50 40 8 40 72 60
Level 1 6 30 50 40 9 45 88 71.5
Level 2 6.5 32.5 56 45 9.5 47.5 92 77.2
Level 3 7 35 62 50 10 50 100 83.3
  1. *BED [Gy 10 ] biologically effective dose for acute reacting tissues (α/β = 10), EQD 2 equivalent dose in 2-Gy fractions