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Table 1 Microarray analysis results from HepG2 and HepaRG® cells

From: microRNA-mediated resistance to hypoglycemia in the HepG2 human hepatoma cell line

miRNA

Glucose (mg/L)

Ratio

mRNA

Glucose (mg/L)

Ratio

900

200

900

200

A-1) The 10 genes showing the great increase in HepG2 cells

 2003miR-150-3p

35.2

185.4

5.27

IFI27

26

281

10.81

 miR-575

97.3

471.9

4.85

HSPA1B

287

2009

7.00

 miR-3158-5p

41.1

173.7

4.23

IF16

22

144

6.55

 miR-593-5p

27.8

112.6

4.05

CMBL

53

296

5.58

 miR-1273e

41.2

164.3

3.99

SULF2

19

106

5.58

 miR-6724-5p

1080.5

4078.7

3.77

CYP1A1

25

135

5.40

 miR-671-5p

71.8

265.8

3.70

CAPN3

54

286

5.30

 miR-4725-3p

141.9

487.1

3.42

DDB2

125

624

4.99

 miR-8059

154.7

520.5

3.36

NT5DC4

24

119

4.96

 miR-373-5p

44.5

144.6

3.25

LY96

160

792

4.95

A-2) The 10 genes showing the great decrease in HepG2 cells

 miR-106a-5p

2174.7

1259.1

0.58

KIF21A

338

38

0.11

 miR-15b-5p

243.3

148.8

0.61

SLCC7A11

273

33

0.12

 miR-93-5p

684.5

421.1

0.62

ANKRD12

354

48

0.14

 miR-20a-5p

1793.2

1219.7

0.68

GOLGA4

249

36

0.14

 miR-17-5p

2144.4

1479.7

0.69

TNKS2

104

15

0.14

 miR-455-3p

213.3

147.6

0.69

MMD

232

34

0.15

 miR-16-5p

1133.7

792.8

0.70

SLC38A2

1313

202

0.15

 miR-19a-3p

381.5

274.8

0.72

ARHGAP18

356

55

0.15

 miR-18a-5p

306.7

220.9

0.72

ZNF12

116

19

0.16

 miR-26b-5p

966.8

775.9

0.78

ATP2B1

244

40

0.16

B-1) The 10 genes showing the great increase in HepaRG® cells

 miR-6829-5p

44.8

102.3

2.28

RGS9

129

280

2.17

 miR-3679-5p

164.8

225.4

1.37

SLC4A7

113

226

2.00

 miR-4675

177.4

234.8

1.32

MY09A

56

112

2.00

 miR-6726-5p

87.3

104.7

1.20

CAMSAP1L1

62

123

1.98

 miR-6799-5p

203.8

238.3

1.17

SDCCAG1

101

197

1.95

 miR-6803-5p

737.2

818.5

1.11

BCL9L

250

483

1.93

 miR-6858-5p

181.7

197.9

1.09

PPHLN1

266

497

1.87

 miR-6779-5p

148.0

148.0

1.07

BAT2L

350

652

1.86

 miR-6721-5p

150.4

150.4

1.06

ZNF783

77

142

1.84

 miR-6819-5p

198.4

198.4

1.05

RRAD

74

136

1.84

B-2) The 10 genes showing the great decrease in HepaRG® cells

 miR-26b-5p

205.5

85.9

0.42

ESD

252

124

0.49

 miR-191-5p

102

44.5

0.44

HMGCS1

4950

2531

0.51

 let-7 g-5p

212.4

101.1

0.48

DDIT3

205

109

0.53

 miR-19b-3p

290.3

138.3

0.48

MAP3K4

107

57

0.53

 miR-20b-5p

103.1

50.0

0.48

GPR125

121

66

0.55

 miR-1246

4912.0

2388.6

0.49

SMAD1

101

55

0.54

 let-7e-5p

215.6

107.8

0.50

WBSCR1

305

167

0.55

 miR-100-5p

208.6

104.3

0.50

PGM3

132

72

0.55

 miR-148a-3p

256.5

130.0

0.51

THRSP

442

253

0.57

 miR-122-3p

215.8

112.9

0.52

PSMB6

1013

600

0.59

  1. The result of microarray analysis of differently expressed miRNAs and mRNAs when HepG2 and HepaRG® cells were cultured in different glucose concentrations. Genes whose expression was greatly altered after the incubation of cells with two different concentrations of glucose, 900 mg/dL and 200 mg/dL, are shown. The 10 genes showing the great increase (A-1, B-1) and the 10 genes showing the greatest decrease (A-2, B-2) from 900 mg/L to 200 mg/L glucose are shown. The difference in the gene expression in HepG2 cells is shown in Table 1A, whereas that of HepaRG cells® is shown in Table 1B
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BMC Cancer

ISSN: 1471-2407

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