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Table 4 Predictive factors for DFS according to univariate and multivariate analyses

From: Clinically suspected T4 colorectal cancer may be resected using a laparoscopic approach

  Univariate analysis Multivariate analysis
  HR 95 % CI P-value HR 95 % CI P-value
Age (years)
 >60 / ≤ 60 1.79 1.06-3.02 0.028 1.86 1.04-3.31 0.036
Sex
 Male / Female 1.11 0.66-1.84 0.702    
BMI (kg/m2)
 >23 / ≤ 23 1.05 0.64-1.75 0.839    
PreOP CEA (ng/ml)
 >5 / ≤ 5 2.28 1.34-3.86 0.002 1.87 1.06-3.30 0.032
Previous abdominal operation
 + / - 1.05 0.59-1.89 0.863    
Combined resection of an adjacent organ
 + / - 1.40 0.82-2.38 0.217    
Tumor location
 Rectum / Colon 2.92 1.76-4.87 <0.001 3.25 1.85-5.74 <0.001
Clinical Obstruction
 + / - 1.14 0.67-1.91 0.634    
Clinical Perforation
 + / - 1.73 0.82-3.63 0.152    
Operative technique
 Laparoscopic / Open 0.77 0.40-1.49 0.435    
Pathologic T stage
 T4 / T2 + T3 1.77 1.07-2.95 0.027 2.22 1.26-3.93 0.006
Pathologic N stage
 + / - 2.20 1.29-3.77 0.004 1.22 0.63-2.36 0.556
Differentiation of cell
 PD + MUC + Signet / WD + MD 1.35 0.73-2.50 0.333    
Lymphatic invasion
 + / - 1.37 0.80-2.33 0.253    
Vascular invasion
 + / - 2.08 1.15-3.75 0.015 1.60 0.79-3.26 0.194
Perineural invasion
 + / - 1.79 0.90-3.56 0.097 0.81 0.38-1.76 0.600
Adjuvant chemotherapy
 + / - 0.65 0.35-1.20 0.169    
  1. PreOP CEA Preoperative carcinoembryonic antigen, WD Well differentiated, MD Moderately differentiated, PD Poorly differentiated, MUC Mucinous adenocarcinoma, signet Signet ring cell type