Table 2 Serum indices from nude mice bearing a BxPC-3 xenograft that were treated orally by gavage with either the vehicle control or DFX (120, 160, or 200Â mg/kg) every second day (three treatments per week) for 21Â days
| Â | Units | Treatment groups | |||
|---|---|---|---|---|---|
Vehicle control | Deferasirox | ||||
120Â mg/kg | 160Â mg/kg | 200Â mg/kg | |||
Ferritin | ng/ml | 18.3 ± 1.9 | 20.6 ± 2.9 | 8.6 ± 1.4* | 9.8 ± 1.5* |
Total protein | g/dl | 5.0 ± 0.3 | 5.4 ± 0.3 | 5.3 ± 0.4 | 5.3 ± 0.3 |
Albumin | g/dl | 3.2 ± 0.2 | 3.3 ± 0.1 | 3.4 ± 0.1 | 3.4 ± 0.1 |
Aspartate aminotransferase | U/l | 89.2 ± 15.8 | 106.2 ± 32.6 | 155.2 ± 97.9 | 146 ± 58.9 |
Alanine transaminase | U/l | 23.6 ± 1.9 | 29.2 ± 8.2 | 28.4 ± 9.6 | 28.8 ± 7.2 |
Lactate dehydrogenase | U/l | 243.6 ± 37.9 | 242.6 ± 18.2 | 243.8 ± 23.1 | 243.6 ± 21.7 |
Blood urea nitrogen | mg/dl | 560.6 ± 112.7 | 578.2 ± 65.5 | 669 ± 43.9 | 689.8 ± 101.9 |
Creatinine | mg/dl | 17.6 ± 1.2 | 14.2 ± 2.1 | 14.4 ± 0.6 | 15.8 ± 1.3 |