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Fig. 1 | BMC Cancer

Fig. 1

From: MET and PTEN gene copy numbers and Ki-67 protein expression associate with pathologic complete response in ERBB2-positive breast carcinoma patients treated with neoadjuvant trastuzumab-based therapy

Fig. 1

Representative images of immunohistochemistry and in situ hybridization studies from three tumors. a: Immunohistochemistry for Ki-67 showing positive staining in greater than 90 % of nuclei in a specimen from Case #2. b: ISH for MET + CEN7 showing reduced MET copy number [silver (black) signals] relative to chromosome 7 [red signals] in a specimen Case #2. c: ISH for PTEN + CEN10 showing gains in PTEN copy number [silver (black) signals] and chromosome 10 copy number [red signals] in a specimen from Case #3. (Original magnification x 600)

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BMC Cancer

ISSN: 1471-2407

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