Fig. 3
SEC62 and vimentin expression in dysplastic cervical lesions. IRS for Sec62 (a) and vimentin (b) immunostaining of uterine cervical smears from 107 women (n = 25 + 25 + 25 + 25 + 7 for no CIN, CIN-I, CIN-II, CIN-III, SCC). The cytological immunoreactive score (IRS) values are illustrated for the respective cytomorphological (right) and histomorphological diagnoses (left). Sec62 and vimentin immunoreactivity of morphologically conspicuous cells was evaluated compared with normal cells of the same smear and valued as weaker (−1), equal (0), slightly more intense (1), moderately more intense (2) or much more intense (3). For each case, the quantitation of 6 independent examiners was toted up to an overall IRS ranging from −6 to 18. In (c), the overall IRS for Sec62 was correlated with the overall IRS for vimentin. The strength of squared correlation is indicated by the squared correlation coefficient (R2)