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Fig. 5 | BMC Cancer

Fig. 5

From: Dactolisib (NVP-BEZ235) toxicity in murine brain tumour models

Fig. 5

a Weight development in healthy, non-tumour bearing NOD/SCID mice during dactolisib exposure (n = 6 for each group). b Kaplan Meyer survival curve for NOD/SCID mice carrying orthotopic GBM xenografts (P3). Left red arrow indicates treatment start of 45 mg/kg dactolisib (n = 7). Right red arrow indicates splitting of control group (n = 7) into one treatment group (25 mg/kg) (n = 3) and one control group (n = 4). Red line shows survival for mice in the treatment group of 45 mg/kg dactolisib, green line shows survival for mice in the treatment group of 25 mg/kg dactolisib, and black line shows survival for mice in the control group (vehicle only). (P-value 0.1788 for 25 mg/kg vs control). c MRI-based assessments of all tumour volumes

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