Fig. 5

a Weight development in healthy, non-tumour bearing NOD/SCID mice during dactolisib exposure (n = 6 for each group). b Kaplan Meyer survival curve for NOD/SCID mice carrying orthotopic GBM xenografts (P3). Left red arrow indicates treatment start of 45 mg/kg dactolisib (n = 7). Right red arrow indicates splitting of control group (n = 7) into one treatment group (25 mg/kg) (n = 3) and one control group (n = 4). Red line shows survival for mice in the treatment group of 45 mg/kg dactolisib, green line shows survival for mice in the treatment group of 25 mg/kg dactolisib, and black line shows survival for mice in the control group (vehicle only). (P-value 0.1788 for 25 mg/kg vs control). c MRI-based assessments of all tumour volumes