Table 2 Pooled HRs (95 % Cl) comparing survival outcomes and recurrence between BRT & CRT

BRT vs. CRT

OS

23

Random

0.32 [0.09, 0.55]

0.006

P < 0.00001; I² = 84.6 %

Positive

BRT vs. CRT

OS for 2-yr

11

Random

0.44 [0.13, 0.76]

0.006

P < 0.0001; I² = 76.9 %

Positive

BRT vs. CRT

OS for 3-yr

12

Random

0.21 [-0.14, 0.55]

0.241

P < 0.00001; I² = 88.8 %

Negative

BRT vs. CRT

PFS

21

Random

0.51 [0.22, 0.80]

0.001

P < 0.00001; I² = 90.1 %

Positive

BRT vs. CRT

PFS for 2-yr

10

Random

0.56 [0.20, 0.92]

0.002

P < 0.00001; I² = 88.2 %

Positive

BRT vs. CRT

PFS for 3-yr

11

Random

0.45 [-0.05, 0.95]

0.076

P < 0.00001; I² = 91.8 %

Negative

BRT vs. CRT

Locoregional control

19

Random

0.49 [0.14, 0.85]

0.007

P < 0.00001; I² = 91 %

Positive

BRT vs. CRT

Locoregional control for 2-yr

9

Random

0.63 [0.09, 1.17]

0.023

P < 0.00001; I² = 83 %

Positive

BRT vs. CRT

Locoregional control for 3-yr

10

Random

0.06 [-0.40, 0.52]

0.808

P < 0.00001; I² = 93.3 %

Negative

BRT vs. CRT

Distant control

5

Random

0.25 [0-0.06, 0.56]

0.118

P < 0.00001; I² = 88.3 %

Negative

BRT vs. CRT

OS for oropharynx

7

Random

0.13 [-0.03, 0.89]

0.743

P < 0.00001; I² = 84.8 %

Negative

BRT vs. CRT

PFS for oropharynx

3

Random

1.56 [1.14, 2.13]

0.006

P < 0.00001; I² = 96 %

Positive

BRT vs. CRT

Locoregional control for oropharynx

6

Random

1.75 [0.6, 5.26]

0.31

P < 0.00001; I² = 89.1 %

Negative

BRT vs. CRT

OS for HPV+

5

Fixed

1.12 [0.46, 2.17]

0.015

P = 0.22; I² = 38 %

Positive

BRT vs. CRT

PFS for HPV+

5

Random

0.80 [0.38, 1.67]

0.55

P < 0.00001; I² = 92 %

Negative

BRT vs. CRT

Locoregional control for HPV+

5

Random

1.17 [0.69, 2.00]

0.56

P = 0.01; I² = 71.1 %

Negative