Fig. 3
From: Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma
Inhibition of PLK1 induces G2-M arrest and apoptosis in DIPG tumor cells. a DIPG cells were treated with IC50 doses of BI 6727 for 24 h and analyzed for changes in cell cycle by flow cytometry. b DIPG cells were treated with varying concentrations of BI 6727 for 72 h and analyzed for Annexin V/7-AAD positive late apoptosis markers by flow cytometry. The percent of cells in late apoptosis ± SEM is shown