Fig. 1
From: Polo-like Kinase 1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma
PLK1 is overexpressed in DIPG patient samples and cell lines. a Gene expression of a panel of mitotic checkpoint kinases in patients with DIPG versus normal pons. Arrow shows up-regulation of PLK1 in DIPG samples. b Microarray data analysis of PLK1 gene expression in brainstem, patient DIPG samples, and DIPG cell lines. Expression level ± SEM is shown (c) Gene enrichment analysis of patient DIPG samples compared to normal pons from microarray data for PLK1 associated gene signatures. d Confirmation of elevated PLK1 protein expression in DIPG cell lines compared to normal pons and cerebellum (CB) by western blot. e Western blot analysis of PLK1 protein in normal pons and three patient samples