|  | Usual care | Intervention | Between-groups difference | 95 % CI | Effect size | ||||
---|---|---|---|---|---|---|---|---|---|---|
 | Mean change from baseline | 95 % CI | Effect size | Mean change from baseline | 95 % CI | Effect size | ||||
End of radiotherapy | ||||||||||
 HADS | Anxiety | −0.7 | −1.2, −0.3 | 0.21 | −1.0 | −1.4, −0.6 | 0.29 | −0.2 | −0.8, 0.4 | 0.09 |
Depression | 0.6 | 0.3, 0.9 | 0.21 | −0.2 | −0.6, 0.1 | 0.07 | −0.8 | −1.2, −0.3 | 0.37 | |
 DT |  | 0.1 | −0.3, 0.5 | 0.05 | −0.3 | −0.7, 0.2 | 0.12 | −0.4 | −0.9, 0.2 | 0.15 |
 EPIC-26 | Urinary | −11.0 | −13.4, −8.6 | 0.68 | −9.2 | −11.5, −6.9 | 0.62 | 1.8 | −1.5, 5.1 | 0.12 |
Bowel | −15.7 | −18.4, −12.9 | 1.34 | −12.8 | −15.8, −9.8 | 0.99 | 2.9 | −1.1, 6.9 | 0.16 | |
Sexual | −5.2 | −7.9, −2.5 | 0.18 | −2.8 | −5.5, −0.2 | 0.11 | 2.4 | −1.4, 6.1 | 0.14 | |
Hormonal | −1.8 | −4.0, 0.3 | 0.10 | 0.0 | −2.2, 2.2 | 0.00 | 1.9 | −1.2, 4.9 | 0.14 | |
 SCNS-SF34-R | Physical & daily living | 6.0 | 3.0, 9.1 | 0.27 | 6.8 | 4.0, 9.7 | 0.37 | 0.8 | −3.3, 5.0 | 0.04 |
Psychological | −4.1 | −6.9, −1.3 | 0.20 | −6.7 | −9.4, −4.0 | 0.32 | −2.6 | −6.5, 1.3 | 0.15 | |
Sexuality | −3.8 | −7.8, 0.2 | 0.13 | −4.9 | −9.3, −0.5 | 0.17 | −1.1 | −7.0, 4.8 | 0.04 | |
Patient care and support | 0.2 | −2.5, 2.9 | 0.01 | −0.8 | −3.9, 2.3 | 0.05 | −1.0 | −5.1, 3.1 | 0.05 | |
Health system & information | −6.9 | −11.0, −2.9 | 0.23 | −7.6 | −12.4, −2.8 | 0.26 | −0.7 | −6.9, 5.6 | 0.02 | |
 CaTS | Sensory/psychological | −0.6 | −0.7, −0.5 | 0.64 | −0.7 | −0.8, −0.5 | 0.72 | −0.1 | −0.3, 0.1 | 0.10 |
Procedural | −0.7 | −0.9, −0.6 | 0.71 | −1.0 | −1.1, −0.8 | 0.86 | −0.2 | −0.5, −0.02 | 0.24 | |
6Â months post-radiotherapy | ||||||||||
 HADS | Anxiety | −0.6 | −1.1, −0.2 | 0.18 | −0.6 | −1.1, −0.1 | 0.18 | 0.0 | −0.7, 0.7 | 0.01 |
Depression | 0.4 | 0.04, 0.8 | 0.16 | 0.1 | −0.3, 0.5 | 0.04 | −0.3 | −0.9, 0.2 | 0.14 | |
 DT |  | −0.3 | −0.6, 0.04 | 0.14 | −0.5 | −0.8, −0.2 | 0.21 | −0.2 | −0.7, 0.3 | 0.10 |
 EPIC-26 | Urinary | −1.0 | −2.9, 0.9 | 0.06 | −2.2 | −4.5, 0.1 | 0.15 | −1.2 | −4.2, 1.8 | 0.09 |
Bowel | −6.8 | −9.4, −4.3 | 0.55 | −6.2 | −8.5, −3.9 | 0.57 | 0.6 | −2.8, 4.1 | 0.04 | |
Sexual | −4.4 | −8.0, −0.9 | 0.15 | −2.1 | −5.1, 0.9 | 0.08 | 2.3 | −2.4, 7.1 | 0.11 | |
Hormonal | −0.8 | −3.2, 1.6 | 0.05 | 1.3 | −1.3, 4.0 | 0.07 | 2.2 | −1.4, 5.7 | 0.14 | |
 SCNS-SF34-R | Physical & daily living | 1.7 | −1.4, 4.8 | 0.07 | 3.4 | 0.7, 6.1 | 0.19 | 1.8 | −2.3, 5.9 | 0.10 |
Psychological | −7.2 | −10.2, −4.3 | 0.35 | −8.0 | −10.8, −5.3 | 0.39 | −0.8 | −4.9, 3.3 | 0.04 | |
Sexuality | 0.0 | −4.6, 4.5 | 0.00 | −1.2 | −5.5, 3.1 | 0.04 | −1.2 | −7.4, 5.1 | 0.04 | |
Patient care and support | −3.5 | −6.1, −1.0 | 0.20 | −1.7 | −4.9, 1.5 | 0.10 | 1.8 | −2.3, 5.9 | 0.10 | |
Health system & information | −10.9 | −14.9, −7.0 | 0.37 | −13.4 | −17.8, −9.0 | 0.46 | −2.5 | −8.4, 3.5 | 0.09 |