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Table 3 Mixed models results for primary and secondary outcomes: estimates of fixed effects

From: Nurse-led group consultation intervention reduces depressive symptoms in men with localised prostate cancer: a cluster randomised controlled trial

Parameter

HADS

DT

EPIC-26

 

Anxiety

Depression

 

Bowel

Urinary

Sexual

Hormonal

 

est

 

s.e.

est

 

s.e.

est

 

s.e.

est

 

s.e.

est

 

s.e.

est

 

s.e.

est

 

s.e.

Intercept

3.9

*

0.4

1.5

**

0.3

1.5

**

0.3

94.5

**

1.9

85.0

**

2.0

38.6

**

3.1

92.2

**

1.9

Time

−1.3

**

0.4

0.8

**

0.3

−0.2

 

0.3

−24.7

**

2.5

−14.2

**

2.1

−4.4

 

2.3

0.1

 

1.8

Quadtime

0.3

**

0.1

−0.2

*

0.1

0.0

 

0.1

5.9

**

0.6

3.6

**

0.5

0.8

 

0.5

−0.1

 

0.4

Group

0.6

 

0.5

1.0

*

0.5

0.3

 

0.3

1.0

 

2.6

0.2

 

2.6

−5.7

 

4.2

−5

 

2.6

Site

1.1

*

0.6

1.1

*

0.5

0.7

 

0.3

−2.2

 

2.3

−1.1

 

2.4

−2.4

 

3.9

−2.2

 

2.4

Pre-BL ADT

1.3

*

0.5

2.2

**

0.5

0.8

**

0.3

−0.9

 

2.4

0.3

 

2.0

−16.6

**

2.9

−20.4

**

1.6

Group × Site

−1.4

*

0.7

−1.4

*

0.6

−0.8

 

0.4

1.7

 

2.8

1.0

 

3.2

1.3

 

5.2

4.8

 

3.2

Group × Pre-BL ADT

         

−5.2

 

3.0

         

Site × Pre-BL ADT

−2.3

**

0.7

−1.6

**

0.6

−1.0

 

0.4

            

Group × Time

−0.3

 

0.4

−1.0

**

0.3

−0.5

 

0.3

3.6

 

2.5

2.2

 

2.1

2.7

 

2.4

2.3

 

1.9

Group × Quadtime

0.1

 

0.1

0.2

**

0.1

0.1

 

0.1

−0.9

 

0.6

−0.7

 

0.5

−0.5

 

0.6

−0.4

 

0.5

Time × Site

0.5

 

0.4

0.4

 

0.3

0.6

 

0.3

5.6

*

2.5

3.5

 

2.1

−4.2

 

2.4

−4.2

*

2.0

Quadtime × Site

−0.1

 

0.1

−0.1

 

0.1

−0.1

 

0.1

−1.5

*

0.6

−0.9

 

0.5

0.9

 

0.6

1.0

*

0.5

Time × Pre-BL ADT

0.2

**

0.1

−0.9

**

0.3

   

4.2

 

2.7

−6.9

**

2.3

1.2

*

0.6

   

Quadtime × Pre-BL ADT

   

0.2

*

0.1

   

−1.2

 

0.6

1.5

**

0.5

      

Parameter

SCNS-SF34-R

CaTS

 

Psychological

Health system & information

Patient care & support

Physical & daily living

Sexuality

Procedural

Sensory/ psychological

Intercept

18.8

**

2.5

26.4

**

3.0

8.7

**

2.0

6.4

**

2.4

20.3

**

3.3

2.6

**

0.1

2.1

**

0.1

Time

−7.2

**

2.3

−9.0

**

3.5

0.3

 

2.4

8.2

**

2.5

−5.2

 

3.4

−0.8

**

0.1

−0.6

**

0.1

Quadtime

1.2

*

0.5

1.4

 

0.8

−0.4

 

0.6

−1.9

**

0.6

1.1

 

0.8

      

Group

4.2

 

3.2

0.3

 

3.9

1.3

 

2.7

1.7

 

3.1

5.4

 

4.4

0.0

 

0.2

0.1

 

0.1

Site

7.1

*

3.2

−0.3

 

3.7

3.4

 

2.5

7.5

*

2.9

6.7

 

4.1

0.0

 

0.1

0.2

 

0.1

Pre-BL ADT

9.0

**

3.0

6.7

**

2.5

4.4

**

1.7

9.3

**

2.0

7.4

*

2.9

0.2

*

0.1

0.2

**

0.1

Group × Site

−10.0

**

3.8

−2.4

 

4.7

−3.9

 

3.2

−6.3

 

3.8

−7.8

 

5.4

0.0

 

0.2

−0.1

 

0.2

Site × Pre-BL ADT

−9.0

*

4.0

                  

Group × Time

−3.2

 

2.5

−0.9

 

3.8

−1.7

 

2.7

1.0

 

2.7

−1.5

 

3.7

−0.2

*

0.1

−0.1

 

0.1

Group × Quadtime

0.7

 

0.6

0.1

 

0.9

0.6

 

0.6

−0.1

 

0.6

0.3

 

0.9

      

Time × Site

3.9

 

2.5

1.3

 

3.9

0.4

 

2.7

−0.6

 

2.7

0.4

 

3.7

0.2

 

0.1

0.1

 

0.1

Quadtime × Site

−0.7

 

0.6

0.0

 

0.9

0.1

 

0.6

0.1

 

0.6

0.2

 

0.9

      
  1. The coefficient for each group by time interaction represents the average difference in rate of change for the intervention group relative to the usual care group. The coefficient for each group by quadtime interaction represents the average difference in “change” in the rate of change (acceleration or deceleration) for the intervention group relative to the usual care group
  2. Time represents average number of months since first assessment. Reference categories: group, usual care; site, Site 2; and pre-BL ADT, no. Time modelled as a random effect for HADS Anxiety and Depression, EPIC-26 Hormonal and Sexual Summary and SCNS-SF34-R Psychological and Sexuality. Terms for the interaction between Pre-BL ADT and Group, Time and Quadtime were not included in the final models for SCNS-SF34-R and CaTS subscales. In all other cases where the estimate of a coefficient is not provided, the relevant term was not included in the final model. * p < .05; ** p < .01
  3. Variance components are available from the authors
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BMC Cancer

ISSN: 1471-2407

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