Table 1 Summary of pathways associated with volumetric tumor phenotype features of the original volumes (top rows) and their ratios (bottom rows)
| Â | Biological processes (positive correlation) | Biological processes (negative correlation) |
|---|---|---|
Volume | Â | Â |
 Necrosis |  | Immune response, apoptosis |
 Contrast Enhancement |  | Signal transduction |
 Edema | Homeostasis | Cell cycle, proliferation, replication, DNA repair, DNA metabolic process |
 Tumor Bulk |  | Apoptosis, signal transduction, immune system |
 Total Volume |  | Synaptogenesis, biogenesis, extracellular structure organization |
Ratios | Â | Â |
 Necrosis/Total Volume |  | Defense response, immune response, Nf-kB, signal transduction |
 Contrast Enhancement/Tumor Volume |  | Protein complex assembly, signal transduction, biogenesis |
 Edema/Tumor Volume | Protein complex assembly, defense response, signal transduction, cytokine production, immune response, Nf-kB |  |
 Tumor Bulk/Tumor Volume |  | Signal transduction, protein complex assembly, cytokine, immune response, Nf-kB |
 Necrosis/Contrast Enhancement |  | Response to other organism, Nf-kB, immune response, locomotory behaviour |
 Contrast Enhancement/Tumor Bulk | Response to other organism, Nf-kB, immune response, locomotory behaviour |  |