Table 2 Association between statin use after diagnosis and breast cancer-specific and all-cause mortality in patients with breast cancer
From: Statin use and breast cancer survival: a nationwide cohort study in Scotland
Breast cancer mortality | Patients | Person years | Age-adjusted HR (95 % CI) | P | Adjusteda HR (95 % CI) | P | |
|---|---|---|---|---|---|---|---|
[n = 15,140] | [n = 13,060] | ||||||
Breast cancer mortality | |||||||
Statin non-user | 855 | 10,907 | 30,852 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
Statin user | 335 | 4,233 | 10,421 | 0.87 (0.76,0.99) | 0.04 | 0.95 (0.79,1.15) | 0.62 |
1-12 prescriptions | 201 | 1,358 | 5,713 | 0.91 (ref. cat.) | 0.22 | 0.94 (0.75,1.18) | 0.61 |
≥12 prescriptions | 134 | 2,875 | 4,708 | 0.82 (0.68,0.99) | 0.04 | 0.97 (0.75,1.25) | 0.79 |
Simvastatin non-user | 966 | 12,115 | 33,845 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
Simvastatin user | 224 | 3,025 | 7,428 | 0.82 (0.71,0.95) | 0.01 | 0.89 (0.73,1.08) | 0.24 |
Lipophilic non-user | 964 | 12,110 | 33,836 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
Lipophilic user | 226 | 3,030 | 7,437 | 0.83 (0.72,0.96) | 0.01 | 0.90 (0.74,1.11) | 0.33 |
Hydrophilic non-user | 1,062 | 13,434 | 37,389 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
Hydrophilic user | 128 | 1,706 | 3,884 | 0.95 (0.79,1.14) | 0.57 | 0.97 (0.76,1.24) | 0.82 |
All-cause mortality | |||||||
Statin non-user | 1,323 | 10,907 | 30,852 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
Statin user | 684 | 4,233 | 10,421 | 0.95 (0.86,1.04) | 0.27 | 0.88 (0.76,1.01) | 0.07 |
1–12 prescriptions | 365 | 1,358 | 5,713 | 0.92 (0.82,1.04) | 0.20 | 0.86 (0.73,1.02) | 0.08 |
≥12 prescriptions | 319 | 2,875 | 4,708 | 0.98 (0.86,1.11) | 0.74 | 0.90 (0.75,1.08) | 0.27 |
Simvastatin non-user | 1,527 | 12,115 | 33,845 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
Simvastatin user | 480 | 3,025 | 7,428 | 0.93 (0.84,1.04) | 0.21 | 0.87 (0.75,1.00) | 0.06 |
Lipophilic non-user | 1,525 | 12,110 | 33,836 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
Lipophilic user | 482 | 3,030 | 7,437 | 0.94 (0.85,1.04) | 0.23 | 0.87 (0.75,1.01) | 0.072 |
Hydrophilic non-user | 1,764 | 13,434 | 37,389 | 1.00 (ref. cat.) | 1.00 (ref. cat.) | ||
Hydrophilic user | 243 | 1706 | 3884 | 0.94 (0.83,1.08) | 0.41 | 0.93 (0.77,1.11) | 0.40 |